| Juan Tellez-Girón y Enriquez de Ribera | |
| Honorific-Suffix: | 4th Duke of Osuna |
| Office: | Viceroy of Sicily |
| Term Start: | 1655 |
| Term End: | 1656 |
| Predecessor: | Rodrigo de Sandoval y Mendoza |
| Successor: | Martin de Redin |
| Birth Date: | 15 November 1597 |
| Birth Place: | Peñafiel, Spain |
| Death Date: | 12 October 1656 |
| Death Place: | Palermo, Sicily |
| Nationality: | Spanish |
| Spouse: | Isabel Raimunda de Sandoval y Padilla |
| Children: | Pedro Baltasar Téllez Girón Gaspar Téllez-Girón |
Juan Tellez-Girón y Enriquez de Ribera, 4th Duke of Osuna (15 November 1597 - 12 October 1656) was Viceroy of Sicily from 1655 to 1656. He was the only male descendant of Pedro Téllez-Girón, 3rd Duke of Osuna who was born in December 1579, and was Viceroy of Sicily from 1610 to 1615 and Viceroy of Naples from 1615 to 1620. His mother was Catalina Enriquez de Ribera y Cortés who died in November 1635 and was one of 3 daughters of Fernando Enriquez, 2nd Duke of Alcalá de los Gazules.
He married Isabel Raimunda de Sandoval y Padilla, who died in 1658 and was the daughter of Cristóbal de Sandoval, Duke of Uceda. They had two children: