Jpx (gene) explained
In molecular biology, JPX transcript, XIST activator (non-protein coding), also known as Jpx, is a long non-coding RNA. In humans, it is located on the X chromosome. It was identified during sequence analysis of the X inactivation centre, surrounding the Xist gene.[1] Jpx upregulates expression of Xist.[2]
See also
Further reading
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
- Tsuritani K, Irie T, Yamashita R, etal . Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. . Genome Res. . 17 . 7 . 1005–1014 . 2007 . 17567985 . 10.1101/gr.6030107 . 1899111.
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Kolesnikov NN, Elisafenko EA . [Comparative organization and the origin of noncoding regulatory RNA genes from X-chromosome inactivation center of human and mouse]. . Genetika . 46 . 10 . 1386–1391 . 2010 . 21254562 .
Notes and References
- Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L, etal . Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine. . Genome Res . 2002 . 12 . 6 . 894–908 . 12045143 . 10.1101/gr.152902 . 1383731 .
- Tian D, Sun S, Lee JT . The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. . Cell . 2010 . 143 . 3 . 390–403 . 21029862 . 10.1016/j.cell.2010.09.049 . 2994261 .
