Joseph Mougous Explained

Joseph D. Mougous
Birth Date:1976
Workplaces:University of Washington
Alma Mater:Western Washington University (BS)
University of California, Berkeley (PhD)
Awards:Burroughs Wellcome Investigator in the Pathogenesis of Infectious Disease (2011)
NAS Award in Molecular Biology (2021)
Election to the National Academy of Sciences (2022)
Website:https://mougouslab.org/

Joseph Mougous is an American microbiologist. He is a Professor of Microbiology, the Lynn M. and Michael D. Garvey Endowed Chair in Gastroenterology, the Director of the Microbial Interactions & Microbiome Center, and a Howard Hughes Medical Institute Investigator at the University of Washington.[1] Mougous is best known for contributions to the field interbacterial antagonism, including discovering the antibacterial activity of the Type VI secretion system (T6SS).[2]

Education

Mougous graduated from Western Washington University with a BS in Chemistry in 1999. While there, he performed research in the laboratory of Professor David Patrick, using scanning tunnelling microscopy to study liquid crystals.[3] Mougous was recognized as the Outstanding Chemistry Graduate at Western Washington University in 1999.[4] [5] He then pursued his Ph.D. at University of California-Berkeley under the mentorship of Carolyn Bertozzi, where he worked on the identification, characterization, and biosynthesis of sulfated metabolites in mycobacteria (including Mycobacterium tuberculosis).[6] [7]

After receiving his PhD in 2004, Mougous joined the laboratory of John Mekalanos at Harvard Medical School as a Damon Runyon Postdoctoral Fellow.[8] [9] There, he demonstrated that a previously uncharacterized gene cluster in Pseudomonas aeruginosa encodes a specialized protein secretion system (now referred to as a type VI secretion system, T6SS).[10]

Research and career

Mougous joined the faculty as an Assistant Professor in the Department of Microbiology at the University of Washington in 2008. He is currently the Lynn M. and Michael D. Garvey Endowed Chair in Gastroenterology and the Director of the Microbial Interactions & Microbiome Center at the University of Washington.[11]

In 2010, Mougous’ laboratory reported that the T6SS of P. aeruginosa targets toxins to other bacterial cells.[12] Subsequently, Mougous and co-workers put forth the hypothesis that interbacterial antagonism is a general feature of the T6SS,[13] and the Mougous lab was the first to demonstrate interspecies targeting by the T6SS. His group was also first to identify the molecular target of a T6SS antibacterial toxin, peptidoglycan, and they went on to identify numerous additional molecular targets of T6SS toxin superfamilies.[14] [15] [16] [17] [18] The Mougous lab also contributed early findings supporting the concept that the T6SS helps shape the composition of human-associated microbial communities.[19] [20] In 2020, the Mougous group published a collaborative study with David R. Liu of Harvard University in which they repurposed a mutagenic antibacterial toxin from Burkholderia, DddA, into a genome editing tool designed for Mitochondrial DNA.[21]

In addition to work on the T6SS, the Mougous lab demonstrated that the Esx pathway (also known as the Type VII secretion system) functions analogously to the T6SS in delivering toxins to competing bacterial cells.[22] Additionally, they described the genetic engineering of an epibiont from the Patescibacteria phylum (also known as the Candidate phyla radiation).[23] [24] [25]

Honors and awards

Notes and References

  1. Web site: Joseph D. Mougous UW Microbiology . 2024-02-28 . microbiology.washington.edu.
  2. Hood . Rachel D. . Peterson . S. Brook . Mougous . Joseph D. . 2017-03-08 . From Striking Out to Striking Gold: Discovering that Type VI Secretion Targets Bacteria . Cell Host & Microbe . 21 . 3 . 286–289 . 10.1016/j.chom.2017.02.001 . 1934-6069 . 6404758 . 28279332.
  3. Mougous . Joseph D. . Brackley . Andrew J. . Foland . Katherine . Baker . Robert T. . Patrick . David L. . Formation of Uniaxial Molecular Films by Liquid-Crystal Imprinting in a Magnetic Field . Physical Review Letters . 20 March 2000 . 84 . 12 . 2742–2745 . 10.1103/PhysRevLett.84.2742 . 11017314 . 2000PhRvL..84.2742M .
  4. Web site: Fall 1999 . Hougen . Denice . Chemical Vibrations Annual Newsletter #2 Fall 1999 . Chemical Vibrations: Annual Newsletter to Alumni and Friends of the Department.
  5. Web site: Sheehan . Kathy . Fall 1998 . Window on Western, 1998, Volume 05, Issue 01 . February 28, 2024 . Western Washington University Western CEDAR.
  6. 2004 . . Mougous . Joseph David . The role of sulfated molecules in Mycobacterium tuberculosis pathogenesis .
  7. Web site: People . 2024-02-28 . Bertozzi Group . en-US.
  8. Web site: Alumni - Mekalanos Lab . 2024-02-28 . mekalanoslab.med.harvard.edu.
  9. Web site: Eight Damon Runyon alumni elected to the National Academy of Sciences . 2024-02-29 . Damon Runyon . en.
  10. Mougous . Joseph D. . Cuff . Marianne E. . Raunser . Stefan . Shen . Aimee . Zhou . Min . Gifford . Casey A. . Goodman . Andrew L. . Joachimiak . Grazyna . Ordoñez . Claudia L. . Lory . Stephen . Walz . Thomas . Joachimiak . Andrzej . Mekalanos . John J. . A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus . Science . 9 June 2006 . 312 . 5779 . 1526–1530 . 10.1126/science.1128393 . 2800167 . 16763151 . 2006Sci...312.1526M .
  11. Web site: About . 2024-02-29 . Microbial Interactions & Microbiome Center . en-US.
  12. Hood . Rachel D. . Singh . Pragya . Hsu . FoSheng . Güvener . Tüzün . Carl . Mike A. . Trinidad . Rex R.S. . Silverman . Julie M. . Ohlson . Brooks B. . Hicks . Kevin G. . Plemel . Rachael L. . Li . Mo . Schwarz . Sandra . Wang . Wenzhuo Y. . Merz . Alexey J. . Goodlett . David R. . Mougous . Joseph D. . A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria . Cell Host & Microbe . January 2010 . 7 . 1 . 25–37 . 10.1016/j.chom.2009.12.007 . 20114026 . 2831478 .
  13. Schwarz . Sandra . Hood . Rachel D. . Mougous . Joseph D. . What is type VI secretion doing in all those bugs? . Trends in Microbiology . December 2010 . 18 . 12 . 531–537 . 10.1016/j.tim.2010.09.001 . 20961764 . 2991376 .
  14. Russell . Alistair B. . Hood . Rachel D. . Bui . Nhat Khai . LeRoux . Michele . Vollmer . Waldemar . Mougous . Joseph D. . 2011 . Type VI secretion delivers bacteriolytic effectors to target cells . Nature . en . 475 . 7356 . 343–347 . 10.1038/nature10244 . 21776080 . 3146020 .
  15. Russell . Alistair B. . Singh . Pragya . Brittnacher . Mitchell . Bui . Nhat Khai . Hood . Rachel D. . Carl . Mike A. . Agnello . Danielle M. . Schwarz . Sandra . Goodlett . David R. . Vollmer . Waldemar . Mougous . Joseph D. . A Widespread Bacterial Type VI Secretion Effector Superfamily Identified Using a Heuristic Approach . Cell Host & Microbe . May 2012 . 11 . 5 . 538–549 . 10.1016/j.chom.2012.04.007 . 22607806 . 3358704 .
  16. Russell . Alistair B. . LeRoux . Michele . Hathazi . Krisztina . Agnello . Danielle M. . Ishikawa . Takahiko . Wiggins . Paul A. . Wai . Sun Nyunt . Mougous . Joseph D. . Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors . Nature . April 2013 . 496 . 7446 . 508–512 . 10.1038/nature12074 . 23552891 . 3652678 . 2013Natur.496..508R .
  17. Whitney . John C. . Quentin . Dennis . Sawai . Shin . LeRoux . Michele . Harding . Brittany N. . Ledvina . Hannah E. . Tran . Bao Q. . Robinson . Howard . Goo . Young Ah . Goodlett . David R. . Raunser . Stefan . Mougous . Joseph D. . An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells . Cell . October 2015 . 163 . 3 . 607–619 . 10.1016/j.cell.2015.09.027 . 4624332 . 26456113 .
  18. Ting . See-Yeun . Bosch . Dustin E. . Mangiameli . Sarah M. . Radey . Matthew C. . Huang . Shuo . Park . Young-Jun . Kelly . Katherine A. . Filip . Szymon Krzysztof . Goo . Young Ah . Eng . Jimmy K. . Allaire . Marc . Veesler . David . Wiggins . Paul A. . Peterson . S. Brook . Mougous . Joseph D. . Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins . Cell . November 2018 . 175 . 5 . 1380–1392.e14 . 10.1016/j.cell.2018.09.037 . 6239978 . 30343895 .
  19. Ross . Benjamin D. . Verster . Adrian J. . Radey . Matthew C. . Schmidtke . Danica T. . Pope . Christopher E. . Hoffman . Lucas R. . Hajjar . Adeline M. . Peterson . S. Brook . Borenstein . Elhanan . Mougous . Joseph D. . 2019 . Human gut bacteria contain acquired interbacterial defence systems . Nature . 575 . 7781 . 224–228 . 10.1038/s41586-019-1708-z . 6938237 . 31666699 . 2019Natur.575..224R .
  20. Verster . Adrian J. . Ross . Benjamin D. . Radey . Matthew C. . Bao . Yiqiao . Goodman . Andrew L. . Mougous . Joseph D. . Borenstein . Elhanan . The Landscape of Type VI Secretion across Human Gut Microbiomes Reveals Its Role in Community Composition . Cell Host & Microbe . September 2017 . 22 . 3 . 411–419.e4 . 10.1016/j.chom.2017.08.010 . 5679258 . 28910638 .
  21. Mok . Beverly Y. . de Moraes . Marcos H. . Zeng . Jun . Bosch . Dustin E. . Kotrys . Anna V. . Raguram . Aditya . Hsu . FoSheng . Radey . Matthew C. . Peterson . S. Brook . Mootha . Vamsi K. . Mougous . Joseph D. . Liu . David R. . 2020 . A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing . Nature . 583 . 7817 . 631–637 . 10.1038/s41586-020-2477-4 . 7381381 . 32641830 . 2020Natur.583..631M .
  22. Whitney . John C . Peterson . S Brook . Kim . Jungyun . Pazos . Manuel . Verster . Adrian J . Radey . Matthew C . Kulasekara . Hemantha D . Ching . Mary Q . Bullen . Nathan P . Bryant . Diane . Goo . Young Ah . Surette . Michael G . Borenstein . Elhanan . Vollmer . Waldemar . Mougous . Joseph D . A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria . eLife . 11 July 2017 . 6 . 10.7554/eLife.26938 . free . 28696203 . 5555719 .
  23. Wang . Yaxi . Gallagher . Larry A. . Andrade . Pia A. . Liu . Andi . Humphreys . Ian R. . Turkarslan . Serdar . Cutler . Kevin J. . Arrieta-Ortiz . Mario L. . Li . Yaqiao . Radey . Matthew C. . McLean . Jeffrey S. . Cong . Qian . Baker . David . Baliga . Nitin S. . Peterson . S. Brook . Mougous . Joseph D. . Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle . Cell . October 2023 . 186 . 22 . 4803–4817.e13 . 10.1016/j.cell.2023.08.017 . 37683634 . 10633639 .
  24. News: Learn . Joshua Rapp . Diving Deep into the Mouth's Microbial Dark Matter . Discover Magazine . 23 October 2023 .
  25. Genetic tools probe microbial dark matter . ScienceDaily . University of Washington School of Medicine/UW Medicine . 7 September 2023 .
  26. Web site: Fellow Detail . 2024-02-28 . ra.nas.edu.
  27. Web site: Grant Recipients . 2024-02-29 . Burroughs Wellcome Fund . en-US.
  28. Web site: Science X Network :: Phys.org, Medical Xpress, Tech Xplore . 2024-02-29 . sciencex.com.
  29. Web site: Joseph D. Mougous, PhD Investigator Profile 2015-Present . 2024-02-29 . www.hhmi.org . en.
  30. Web site: National Finalists Blavatnik Awards for Young Scientists . 2024-03-11 . blavatnikawards.org.
  31. Web site: NAS Award in Molecular Biology . 2024-03-11 . www.nasonline.org.
  32. Web site: Four UW researchers elected to the National Academy of Sciences for 2022 . 2024-02-29 . UW News . en.

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