| Official Name: | José Santos Guardiola |
| Pushpin Map: | Honduras |
| Pushpin Label Position: | right |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Honduras |
| Subdivision Type: | Country |
| Subdivision Name: |  Honduras |
| Subdivision Type1: | Department |
| Subdivision Name1: | Bay Islands |
| Leader Title: | Mayor |
| Leader Name: | Carson Dilbert |
| Area Total Km2: | 64.37 |
| Population As Of: | 2013 |
| Population Footnotes: | [1] |
| Settlement Type: | Municipality |
| Population Total: | 11,334 |
| Population Density Km2: | auto |
| Timezone: | CST |
| Utc Offset: | -6 |
| Coordinates: | 16.4°N -107°W |
| Elevation M: | 235 |
José Santos Guardiola is a municipality in the Bay Islands Department of Honduras.[2] It is located on the island of Roatán. The name of the municipality is in honor of Brigadier General José Santos Guardiola Bustillo, President of Honduras between 1856 and 1862. The capital of the municipality is Oakridge.
The municipality was created by presidential decree, issued in 1960.