| José Rafael Larraín | |
| Birth Date: | 1813 2, df=y |
| Birth Place: | Buin, Chile |
| Death Place: | Santiago, Chile |
| Nationality: | Chilean |
| Office1: | President of the Senate of the Republic of Chile |
| Term Start1: | 1864 |
| Term End1: | June 1864 |
| Predecessor1: | Manuel José Cerda |
| Successor1: | Manuel Antonio Tocornal Grez |
| Party: | Conservative Party |
| Occupation: | Politician |
José Rafael Larraín Moxó (born 16 February 1813 – 28 December 1892) was a Chilean politician who served as President of the Senate of Chile.