| José María Alpuche e Infante | |
| Office: | President of the Chamber of Deputies |
| Term Start: | 1 January 1830 |
| Term End: | 31 December 1830 |
| Successor: | Joaquín Cázares y Armas |
| Birth Date: | 9 October 1780 |
| Birth Place: | San Francisco de Campeche, Captaincy General of Yucatán, New Spain |
| Death Place: | Mexico City, Centralist Republic of Mexico |
| Party: | Liberal Party |
| Otherparty: | York Rite |
José María Alpuche e Infante (9 October 1780 – 10 December 1840) was a Mexican priest, politician, public speaker and writer. During his performance in politics he radically defended federalism and was a member of the York Masonic lodge.
He completed his ecclesiastical studies at the San Ildefonso Conciliar Seminary in Mérida. He studied philosophy as a partner with Andrés Quintana Roo, Lorenzo de Zavala and Manuel Jiménez Solís. He was a disciple of Pablo Moreno. While acting as a priest in Cunduacán, he was elected deputy to the central Congress to represent the state of Tabasco. Like Miguel Ramos Arizpe and Lorenzo de Zavala, he belonged to the Yorkine lodge, he was its founder in the city of Toluca. He greatly supported the appointment of Vicente Guerrero to the presidency of the country. He collaborated for the newspapers El Correo de la Federación, El Águila, La Gaceta and El Federalista in Mexico City and Yucatán.
When the Congress declared Vicente Guerrero disqualified from exercising the presidency, and Anastasio Bustamante replaced him, he was exiled to New Orleans in the company of and other federalist legislators, who were considered opponents to the new regime. Alpuche returned to Mexico shortly after Bustamante handed over the presidency to Manuel Gómez Pedraza, after the had been signed.
As a senator, he openly criticized the centralist regime. In 1838, Bustamante ordered the apprehension of Valentín Gómez Farías and José María Alpuche. Alpuche was taken to prison in the Santo Domingo Convent. Far from being intimidated, he continued to publish polemics and agitated the population against the centralist regime. He spent the last years of his life in prison, where he died on 10 December 1840.