| José Manuel Restrepo Vélez | |
| Order: | 1st |
| Office: | Ministry of the Interior (Colombia)Secretary of the Interior of Colombia |
| Term Start: | 7 October 1821 |
| Term End: | 1830 |
| President: | Simón Bolívar y Palacios |
| Order2: | 3rd |
| Office2: | Ministry of Foreign Affairs (Colombia)Secretary of Foreign Affairs of Colombia |
| President2: | Simón Bolívar y Palacios |
| Predecessor2: | José Rafael Revenga y Hernández |
| Successor2: | José Rafael Revenga y Hernández |
| Office3: | Governor of Antioquia |
| Term Start4: | 2 September 1819 |
| Term End4: | 9 April 1821 |
| Appointed4: | José María Córdova Muñoz |
| Predecessor4: | José María Córdova Muñoz |
| Successor4: | José María Ricaurte y Nariño |
| Birth Date: | 30 December 1781 |
| Birth Place: | Envigado, Antioquia, Viceroyalty of the New Granada |
| Death Place: | Bogotá, Cundinamarca, Granadine Confederation |
| Nationality: | Neogranadine |
| Spouse: | (1812–1863) |
| Alma Mater: | College of Saint Bartholomew (LLB, 1808) |
| Profession: | Lawyer |
| Signature: | José Manuel Restrepo signature.png |
| Signature Alt: | J Manuel Restrepo |
José Manuel Restrepo Vélez (30 December 1781 – 1 April 1863)[1] was an investigator of Colombian flora, political figure and historian. The orchid genus Restrepia was named in his honor.
Restrepo was born in the town of Envigado, Antioquia in the Colombian Mid-west. He graduated as a lawyer from the Colegio de San Bartolomé in the city of Santa Fe de Bogotá. He later worked as Secretary for Juan del Corral and Governor Dionisio Tejada during their dictatorial government over Antioquia.
From 1811 to 1814 he became a Deputy Representative of Antioquia during the Congress of the United Provinces of New Granada. After the Independence from Spain was achieved by Simon Bolivar, Restrepo became governor of Antioquia in 1819 during the Greater Colombia.
Restrepo was profoundly interested in geography and fauna of Antioquia.