| José López Portillo y Rojas | |
| Office1: | Governor of Jalisco |
| Term Start1: | October 23, 1912 |
| Term End1: | February 10, 1914 |
| Predecessor1: | Alberto Robles Gil |
| Successor1: | José M. Mier |
| Office2: | Secretary of Foreign Affairs of Mexico |
| President2: | Victoriano Huerta |
| Term Start2: | February 17, 1914 |
| Term End2: | July 10, 1914 |
| Predecessor2: | Querido Moheno |
| Successor2: | Francisco S. Carvajal |
| Birth Date: | 26 May 1850 |
| Birth Place: | Guadalajara, Jalisco |
| Death Place: | Mexico DF |
| Nationality: | Mexican |
| Relations: | José López Portillo y Pacheco (grandson) |
| Profession: | lawyer, politician |
José López Portillo y Rojas (May 26, 1850 – May 22, 1923), born in Guadalajara, Jalisco, was a Mexican lawyer, politician and man of letters. He served as Governor of Jalisco in 1911 and as Secretary of Foreign Affairs in 1914 for coup leader and brief Mexican President Victoriano Huerta, during the United States occupation of Veracruz. He served as Director of the Mexican Academy of Language from 1916 to 1923.
His grandson José López Portillo y Pacheco, was the president of Mexico from 1976 to 1982.
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