| José Guedes Brandão de Melo | |
| Birth Date: | 30 October 1846 |
| Birth Place: | Massarelos, Porto |
| Death Date: | 23 September 1919 |
| Nationality: | Portuguese |
| Office: | Colonial governor of Cape Verde |
| Term Start: | 4 February 1890 |
| Term End: | 5 September 1893 |
| Predecessor: | Augusto César Cardoso de Carvalho |
| Successor: | Alexandre Alberto da Rocha de Serpa Pinto |
José Guedes Brandão de Melo (30 October 1846 – 23 September 1919) was a Portuguese colonial administrator and a military officer. He was a son of Francisco Brandão de Melo Cogominho and Maria da Natividade Guedes de Carvalho e Meneses, who was a sister of José and Vasco Guedes de Carvalho e Meneses.[1] On 10 May 1876, he married Maria dos Prazeres Mimoso da Costa Pereira Alpoim de Carvalho (born 3 March 1859).[1] He was governor general of Cape Verde from 4 February 1890 until 5 September 1893.[2]