| José Guadalupe Osuna | |
| Birth Date: | December 10, 1955[1] |
| Order: | 14th |
| Office: | Governor of Baja California |
| Term Start: | 1 November 2007 |
| Term End: | 31 October 2013 |
| Predecessor: | Eugenio Elorduy |
| Successor: | Francisco Vega de Lamadrid |
| Order2: | 16th |
| Office2: | Municipal President of Tijuana |
| Term Start2: | 1 November 1995 |
| Term End2: | 31 October 1998 |
| Predecessor2: | Héctor Osuna Jaime |
| Successor2: | Francisco Vega de Lamadrid |
| Party: | PAN |
| Spouse: | Carmina Capuchino de Osuna |
José Guadalupe Osuna Millán (born December 10, 1955) is a Mexican economist and politician member of the National Action Party (PAN) who served as Governor of Baja California.
Osuna graduated in Economics from the Universidad Autónoma de Baja California and has a Master's Degree in Economics from the Instituto Politécnico Nacional.
Osuna worked in the private sector before becoming an active PAN member. He has served as municipal president of Tijuana (1995 - 1998) and as the Director of the State Commission of Water.
In 2003, he was elected as Federal Representative in the LIX Legislature of the Mexican Congress for the V Electoral District of Baja California.
In 2007 he ran as the PAN candidate for Governor of Baja California in the 2007 Baja California state election. Osuna won the election defeating the PRI candidate Jorge Hank. Currently he is leading an effort to crack down on the drug cartels and corruption within the state government.