| José Francisco Urrejola | |
| Birth Date: | 1881 11, df=y |
| Birth Place: | Concepción, Chile |
| Death Place: | Santiago, Chile |
| Nationality: | Chilean |
| Office1: | President of the Senate of Chile |
| Term Start1: | 31 May 1944 |
| Term End1: | 15 May 1945 |
| Predecessor1: | Pedro Opaso |
| Successor1: | Arturo Alessandri Palma |
| Office2: | Member of the Senate of Chile |
| Constituency2: | 2nd Provincial Agrupation (Atacama and Coquimbo) |
| Term Start2: | 15 May 1945 |
| Term End2: | 15 May 1937 |
| Predecessor2: | Luis Álamos Barros |
| Successor2: | Salvador Ocampo |
| Constituency3: | 23rd Departamental Agrupation (Osorno and Río Negro) |
| Term Start3: | 15 May 1926 |
| Term End3: | 1 March 1930 |
| Predecessor3: | Julio Velasco González |
| Successor3: | Santiago Silva Álvarez |
| Constituency4: | 23rd Departamental Agrupation (Osorno and Río Negro) |
| Term Start4: | 15 May 1918 |
| Term End4: | 15 May 1924 |
| Predecessor4: | Enrique Zañartu Prieto |
| Successor4: | Francisco Jorquera Fuhrmann |
| Constituency5: | 23rd Departamental Agrupation (Osorno and Río Negro) |
| Term Start5: | 15 May 1915 |
| Term End5: | 15 May 1918 |
| Predecessor5: | Francisco Concha Cienfuegos |
| Successor5: | Julio Silva Rivas |
| Party: | Conservative Party |
| Occupation: | Politician |
| Profession: | Lawyer |
José Francisco Urrejola Menchaca (born 4 March 1881–28 December 2004) was a Chilean politician and lawyer who served as President of the Senate of Chile.