| José Domingues dos Santos | |
| Office: | Prime Minister of Portugal |
| Term Start: | 22 November 1924 |
| Term End: | 16 February 1925 |
| President: | Manuel Teixeira Gomes |
| Predecessor: | Alfredo Rodrigues Gaspar |
| Successor: | Vitorino Guimarães |
| Birth Date: | 5 August 1885 |
| Birth Place: | Matosinhos, Portugal |
| Death Place: | Porto, Portugal |
José Domingues dos Santos (5 August 1885 - 16 August 1958) was a Portuguese politician, jurist, professor and journalist who, among other positions, served as President of the Council of Ministers (Prime Minister) of one of the many governments of the Portuguese First Republic (1924-1925). He was a member of the free masonry, at least since 1922.