| Jorge Luis Sierra Cruz | |
| Order: | Cuban Minister of Transportation |
| Term Start: | 20 October 2006 |
| Term End: | 3 May 2010 |
| Predecessor: | Carlos Manuel Pazo Torrado |
| Successor: | César Ignacio Arocha |
| Birth Date: | 4 September 1961 |
| Birth Place: | Banes, Holguin |
| Death Date: | Age 54 |
| Death Place: | C.Habana |
| Party: | Communist Party of Cuba |
| Profession: | Mechanical engineer |
Jorge Luis Sierra Cruz (born 4 September 1961 – died 27 October 2014) was a Cuban politician. He was the Cuban Minister of Transportation (since 20 October 2006), the Member of the Political Bureau of the Communist Party of Cuba and the Member of the Executive Committee of CPC. He was a Cuban Vice President since 19 February 2009 till 3 May 2010. He is also a deputy in National Assembly of People's Power. He died after complications from knee surgery, followed by a massive heart attack.