Joomyeong Kim Explained

Joomyeong Kim
Birth Name:Joomyeong Kim
Nationality:American / South Korean
Education:LSU Medical Center at New Orleans, LA (Ph. D.)
Seoul National University (M.S., B.S.)
Alma Mater:LSU Medical Center at New Orleans, LA (Ph. D., 1995)
Field:Genomic imprinting
Epigenetics
Work Institutions:Oak Ridge National Laboratory
Lawrence Livermore National Laboratory
Louisiana State University

Joomyeong Kim is a Russell Thompson, Jr. Family Professor of Biology at Louisiana State University. His research interests include genomic imprinting and epigenetics. Dr. Kim's laboratory is mainly involved in understanding the functions and regulatory mechanisms governing genes subject to genomic imprinting.[1] Having previously characterized an imprinted domain located on proximal mouse chromosome 7/ human chromosome 19q13.4, his laboratory currently focuses on understanding regulatory mechanisms directing the mono-allelic expression of the seven imprinted genes in the cluster: Peg3, Usp29, Zfp264, APeg3 (paternally expressed) and Zim1, Zim2, Zim3 (maternally expressed).[2] [3] [4] [5] [6] [7] [8] As a second project direction, his lab studies the function of the dominant gene in the cluster, Peg3, as a transcriptional regulator.[9] [10] [11] [12] Past projects in the Kim lab have included studying the epigenetic instability of imprinted genes during tumorigenesis,[13] [14] [15] potential roles of AEBP2 as a PRC2 targeting protein and in neural crest cell development,[16] [17] [18] as well as the DNA methylation of mouse and human retrotransposons.[19] [20]

Education

Selected publications

External links

Notes and References

  1. Web site: Joomyeong Kim. Nov 15, 2017.
  2. Kim J, Ekram MB, Kim H, Faisal M, Frey WD, Huang JM, Tran K, Kim MM, Yu S . Imprinting control region (ICR) of the Peg3 domain . Hum Mol Genet . 21 . 12 . 2677–87 . 2012 . 22394678 . 3363340 . 10.1093/hmg/dds092.
  3. Thiaville MM, Kim H, Frey WD, Kim J . Identification of an evolutionarily conserved cis-regulatory element controlling the Peg3 imprinted domain . PLOS ONE . 8 . 9 . e75417 . 2013 . 24040411 . 3769284 . 10.1371/journal.pone.0075417. free .
  4. Kim J, Ye A . Phylogenetic and Epigenetic Footprinting of the Putative Enhancers of the Peg3 Domain . PLOS ONE . 11 . 4 . e0154216 . 2016 . 27104590 . 4841594 . 10.1371/journal.pone.0154216. free .
  5. Perera BP, Kim J . Alternative promoters of Peg3 with maternal specificity . Sci Rep . 6 . 24438 . 2016 . 27075691 . 4830991 . 10.1038/srep24438.
  6. He H, Perera BP, Ye A, Kim J . Parental and sexual conflicts over the Peg3 imprinted domain . Sci Rep . 6 . 38136 . 2016 . 27901122 . 128876 . 10.1038/srep38136.
  7. He H, Ye A, Perera BP, Kim J . YY1's role in the Peg3 imprinted domain . Sci Rep . 7 . 6427 . 2017 . 1 . 28743993 . 5526879 . 10.1038/s41598-017-06817-5.
  8. Bretz CL, Kim J . Transcription-driven DNA methylation setting on the mouse Peg3 locus . Epigenetics . Sep 19 [Epub ahead of print] . 945–952 . 2017 . 11 . 28925797 . 10.1080/15592294.2017.1377869. 5788428 .
  9. Ye A, He H, Kim J. Paternally expressed Peg3 controls maternally expressed Zim1 as a trans factor . PLOS ONE . 9 . 9 . e108596 . 2014 . 25265264 . 4180786 . 10.1371/journal.pone.0108596. free .
  10. Lee S, Ye A, Kim J . DNA-Binding Motif of the Imprinted Transcription Factor PEG3 . PLOS ONE . 10 . 12 . e0145531 . 2015 . 26692216 . 4686966 . 10.1371/journal.pone.0145531. free .
  11. Ye A, He H, Kim J . PEG3 binds to H19-ICR as a transcriptional repressor . Epigenetics . 11 . 12 . 889–900 . 2016 . 27824289 . 5193492 . 10.1080/15592294.2016.1255385.
  12. Ye A, He H, Kim J . PEG3 control on the mammalian MSL complex . PLOS ONE . 12 . 6 . e0178363 . 2017 . 28609438 . 5469463 . 10.1371/journal.pone.0178363. free .
  13. Kim J, Bretz CL, Lee S. Epigenetic instability of imprinted genes in human cancers . Nucleic Acids Res . 43 . 22 . 10689–99 . 2015 . 26338779 . 4678850 . 10.1093/nar/gkv867.
  14. Bretz CL, Langohr IM, Lee S, Kim J . Epigenetic instability at imprinting control regions in a Kras(G12D)-induced T-cell neoplasm . Epigenetics . 10 . 12 . 1111–201 . 2015 . 26507119 . 4844204 . 10.1080/15592294.2015.1110672.
  15. Bretz CL, Langohr IM, Kim J . Epigenetic response of imprinted domains during carcinogenesis . Clin Epigenetics . 9 . 90 . 2017 . 28855972 . 5572065 . 10.1186/s13148-017-0393-8 . free .
  16. Kim H, Kang K, Kim J. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2 . Nucleic Acids Res . 37 . 9 . 2940–50 . 2009 . 19293275. 2685092 . 10.1093/nar/gkp149.
  17. Kim H, Kang K, Ekram MB, Roh TY, Kim J . Aebp2 as an epigenetic regulator for neural crest cells . PLOS ONE . 6 . 9 . e25174 . 2011 . 21949878 . 3176318 . 10.1371/journal.pone.0025174. free .
  18. Kim H, Ekram MB, Bakshi A, Kim J . AEBP2 as a transcriptional activator and its role in cell migration . Genomics . 105 . 2 . 108–15 . 2015 . 25451679 . 4314425 . 10.1016/j.ygeno.2014.11.007.
  19. Bakshi A, Kim J. Retrotransposon-based profiling of mammalian epigenomes: DNA methylation of IAP LTRs in embryonic stem, somatic and cancer cells . Genomics . 104 . 538–44 . 2014 . 6 . 25277721. 4262695 . 10.1016/j.ygeno.2014.09.009.
  20. Bakshi A, Herke SW, Batzer MA, Kim J . ADNA methylation variation of human-specific Alu repeats . Epigenetics . 11 . 2 . 163–73 . 2016 . 26890526 . 4846114 . 10.1080/15592294.2015.1130518.

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