Jonathon Pines Explained

Jonathon Pines
Birth Name:Jonathon Noë Joseph Pines
Birth Date:1961 10, df=yes
Alma Mater:University of Cambridge (BA, PhD)
Thesis Title:Cyclin: a major maternal message in sea urchin eggs
Thesis Url:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233321
Thesis Year:1987
Doctoral Advisor:Tim Hunt
Academic Advisors:Anthony R. Hunter
Doctoral Students:Viji Draviam[1]
Awards:EMBO Member (2001)

Jonathon Noë Joseph Pines [2] (born 11 October 1961) is Head of the Cancer Biology Division at the Institute of Cancer Research in London. He was formerly a senior group leader at the Gurdon Institute at the University of Cambridge.[2] [3]

Education

Pines was educated at the University of Cambridge where he was awarded a PhD in 1987 for research on cyclin in sea urchin eggs[4] supervised by Tim Hunt.[5]

Research and career

Following his PhD, Pines was a postdoctoral researcher supervised by Anthony R. Hunter at the Salk Institute in La Jolla, California[6] [7] [8] [9] before moving to the Gurdon Institute at the University of Cambridge then the Institute of Cancer Research in 2015.[3]

Pines research investigates cyclin, the cell cycle and mitosis. He pioneered the use of fluorescent tags to analyse the dynamic behaviour and stability of these regulators in living cells.

Pines discoveries have revealed that mitotic regulators are targeted to specific substructures at specific times, and that mitosis is exquisitely coordinated by the destruction of key regulators at different times in cell division. Pines work has provided insights into how chromosome behaviour in mitosis controls both the time and the rate at which essential mitotic regulators are destroyed, and these discoveries have wider implications for how cancers develop.

Since 2020, Pines has been Editor-in-Chief of the Royal Society journal Open Biology.

Awards and honours

Pines was elected a member of the European Molecular Biology Organisation (EMBO) in 2001[10] and a Fellow of the Academy of Medical Sciences (FMedSci) in 2005. His citation on election reads:

Pines was elected a Fellow of the Royal Society (FRS) in 2016.[11] [12] [13]

Notes and References

  1. PhD. University of Cambridge. Studies on human B- type cyclins. Viji Mythily. Draviam. 2002. . cam.ac.uk. 894595569.
  2. Web site: Anon. 2016. https://web.archive.org/web/20160510153409/http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/dr-jonathon-pines/. 2016-05-10. Dr Jonathon Pines FMedSci. acmedsci.ac.uk. London.
  3. Web site: https://web.archive.org/web/20160309030608/http://www.gurdon.cam.ac.uk/research/pines. 2016-03-09. Jonathon Pines PhD FMedSci, Cancer Research UK Director of Research in Cell Division, Member of the Zoology Department. University of Cambridge. Cambridge.
  4. PhD. University of Cambridge. Cyclin: a major maternal message in sea urchin eggs. Jonathon Noe Joseph. Pines. 1987. cam.ac.uk. . 499166627.
  5. Pines . Jonathon . Hunt . Tim . 1987 . Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs . . 6 . 10 . 2987–2995. 2826125. 553735 . 10.1002/j.1460-2075.1987.tb02604.x.
  6. Web site: https://web.archive.org/web/20150515223837/http://www.zoo.cam.ac.uk/directory/jonathon-pines. 2015-05-15. Dr Jonathon Pines: Department of Zoology. University of Cambridge. Cambridge.
  7. Pines. Jonathon. Hunter. Tony. Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature. 346. 6286. 1990. 760–763. 10.1038/346760a0. 2143810. 1990Natur.346..760P. 4333058.
  8. Hunter. Tony. Pines. Jonathon. Cyclins and cancer. Cell. 66. 6. 1991. 1071–1074. 10.1016/0092-8674(91)90028-W. 1833062. 29568380.
  9. Hunter. Tony. Pines. Jonathon. Cyclins and cancer II: Cyclin D and CDK inhibitors come of age. Cell. 79. 4. 1994. 573–582. 10.1016/0092-8674(94)90543-6. 7954824. 24867886.
  10. Web site: EMBO member: Jonathon Pines. EMBO. Heidelberg.
  11. Web site: Dr Jonathon Pines FRS . . 2016-04-29 . https://web.archive.org/web/20160429121634/https://royalsociety.org/people/jonathon-pines-12890/ . London . Anon . 2016 . One or more of the preceding sentences incorporates text from the royalsociety.org website where:
  12. Institute of Cancer Research, London
  13. Institute of Cancer Research, London

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