Jonathan Hodgkin Explained

Jonathan Hodgkin
Birth Name:Jonathan Alan Hodgkin
Workplaces:Laboratory of Molecular Biology
Alma Mater:University of Oxford (BA)
University of Cambridge (PhD)
Thesis Title:Genetic and Anatomical Aspects of the Caenorhabditis elegans Male
Thesis Url:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.459309
Thesis Year:1974
Doctoral Advisors:)-->
Notable Students:Magdalena Skipper[1]
Awards:Edward Novitski Prize (2017)
Spouses:)-->
Partners:)-->

Jonathan Alan Hodgkin (born 1949) is a British biochemist. He is the Professor of Genetics at the University of Oxford and an emeritus fellow of Keble College, Oxford.[2]

Education

Hodgkin was educated at the University of Oxford where he graduated in 1971. He was awarded a PhD from the University of Cambridge in 1974 for research on the genetics of the worm Caenorhabditis elegans.[3]

Career and research

Hodgkin was a scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge.[4] Hodgkin was one of the earliest researchers to explore the genetics of development in the nematode worm Caenorhabditis elegans. He first unraveled the genetic and maturational events in worm sex determination before extending his interest to other developmental pathways, behaviour and immunity.

Most Caenorhabditis elegans worms are self-fertilizing hermaphrodites, with two X chromosomes, but X0 males can also arise spontaneously, permitting genetic crosses. Hodgkin used genetic mutations in this tiny, fast-breeding species to define the regulatory cascade of genes that controls the development of male or hermaphrodite characteristics providing a model for approaching development in other species.

Since 2000, Hodgkin has focused on the nematode's response to attack by bacteria, exploring highly conserved pathways of innate immunity that are also relevant to development. Through microarray analysis, he has identified antibacterial factors produced by the worm that could be candidates for new antibiotics. He has also discovered novel pathogenic bacteria that attack nematodes, which may have potential as biological pest control agents against parasitic nematodes.

Awards and honours

Hodgkin was elected a Fellow of the Royal Society (FRS) in 1990.[5] In 2011, he received The Genetics Society Medal.[5] Hodgkin was a member of the Faculty of 1000.[6] He was awarded the Edward Novitski Prize by the Genetics Society of America in 2017.[7]

Personal life

See also: Hodgkin family. Hodgkin is the son of Nobel laureate Alan Lloyd Hodgkin and the editor Marni Hodgkin.

Notes and References

  1. Skipper. M.. Milne. C. A.. Hodgkin. J.. 1999. Genetic and molecular analysis of fox-1, a numerator element involved in Caenorhabditis elegans primary sex determination . Genetics. 151. 2. 617–631 . 10.1093/genetics/151.2.617. 1460491. 9927456.
  2. Web site: Professor Jonathan Hodgkin . keble.ox.ac.uk. Keble College, Oxford . February 14, 2012.
  3. PhD. University of Cambridge. Genetic and Anatomical Aspects of the Caenorhabditis elegans Male. Jonathan Alan. Hodgkin. 1974. . jisc.ac.uk. 500473570.
  4. 10.1016/j.cub.2004.03.015 . Jonathan Hodgkin . 2004 . Hodgkin . Jonathan . Current Biology . 14 . 7 . R259–60 . 15062112. 8464632 . free .
  5. Web site: https://web.archive.org/web/20151117123905/https://royalsociety.org/people/jonathan-hodgkin-11628/. 2015-11-17. Professor Jonathan Hodgkin FRS. royalsociety.org. Royal Society. Anon. 1990. London. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
  6. Web site: Jonathan Hodgkin: Former Member in Developmental Molecular Mechanisms . F1000. f1000.com . 2012-02-14.
  7. Web site: Jonathan Hodgkin awarded the 2017 Novitski Prize. 21 March 2017. genestogenomes.org. 16 April 2019.