| John | |
| Predecessor: | random |
| Spouse: | Soldane Bagrationi of Georgia |
| Issue: | Leo V, King of Armenia |
| House: | Poitiers-Lusignan |
| Father: | Amalric, Lord of Tyre |
| Mother: | Isabella princess of Tyre |
| Death Date: | 7 August 1343 |
John of Poitiers-Lusignan (French: Jean de Poitiers-Lusignan; died 7 August 1343) was constable and later regent of the Armenian Kingdom of Cilicia.
He was son of Amalric, Lord of Tyre, and Isabella of Armenia. His siblings were Guy (Constantine II, King of Armenia) and Agnes, wife of Leo III, King of Armenia.
John married (before 1330) Princess Soldane Bagrationi (d. after 1343), daughter of king George V of Georgia. The couple had a son:
John was murdered in Cilicia on 7 August 1343.