| John Wristen | |
| Birth Date: | 15 April 1962 |
| Birth Place: | Denver, Colorado, U.S. |
| Player Years1: | 1980–1983 |
| Player Team1: | Southern Colorado |
| Player Positions: | Quarterback |
| Coach Years1: | 1991–1998 |
| Coach Team1: | Northwestern (RB/ST) |
| Coach Years2: | 1999–2000 |
| Coach Team2: | Colorado (RB/ST) |
| Coach Years3: | 2001–2005 |
| Coach Team3: | Colorado (TE/ST) |
| Coach Years4: | 2006–2007 |
| Coach Team4: | UCLA (TE/ST) |
| Coach Years5: | 2008–2022 |
| Coach Team5: | CSU Pueblo |
| Overall Record: | 133–37 |
| Tournament Record: | 9–8 (NCAA D-II playoffs) |
| Championships: | 1 NCAA Division II (2014) 8 RMAC (2011–2018) |
John Wristen (born April 15, 1962) is an American former college football coach and player. He was the head football coach at Colorado State University–Pueblo (CSU Pueblo), a position he held from 2008 until his retirement in 2022. He graduated from CSU Pueblo in 1984, when the school was known as the University of Southern Colorado. Wristen led the 2014 CSU Pueblo ThunderWolves football team to the NCAA Division II Football Championship title.