| John Wesley Matthews, Jr. | |
| State Senate: | South Carolina |
| State: | South Carolina |
| District: | 39th |
| Term Start: | 1985 |
| Succeeded: | Vernon Stephens |
| Birth Date: | 21 April 1940 |
| Birth Place: | Bowman, South Carolina |
| Spouse: | Geraldine |
| Profession: | Farmer, educator, businessman |
| Party: | Democratic |
| District1: | 94th |
| State House1: | South Carolina |
| Term End: | 2021 |
| Termend1: | 1984 |
| Termstart1: | 1975 |
| Succeeded1: | Kenneth E. Bailey Sr. |
John Wesley Matthews, Jr. (born April 21, 1940) is a former Democratic member of the South Carolina Senate, representing the 39th District from 1985 to 2020.