| John Samuels Caskie | |
| State: | Virginia |
| District: | 3rd |
| Term Start: | March 4, 1853 |
| Term End: | March 3, 1859 |
| Predecessor: | Thomas H. Averett |
| Successor: | Daniel C. DeJarnette |
| State2: | Virginia |
| District2: | 6th |
| Term Start2: | March 4, 1851 |
| Term End2: | March 3, 1853 |
| Predecessor2: | James Seddon |
| Successor2: | Paulus Powell |
| Birth Date: | November 8, 1821 |
| Birth Place: | Richmond, Virginia |
| Death Place: | Richmond, Virginia |
| Resting Place: | Hollywood Cemetery, Richmond, Virginia |
| Party: | Democratic |
| Profession: | lawyer |
| Alma Mater: | University of Virginia |
John Samuels Caskie (November 8, 1821 - December 16, 1869) was a nineteenth-century congressman, lawyer and judge from Virginia.
Born in Richmond, Virginia, Caskie graduated from the University of Virginia in 1842, studied law and was admitted to the bar in around 1842, commencing practice in Richmond. He was the prosecuting attorney of Richmond from 1842 to 1846 and judge of the Richmond and Henrico circuits from 1846 to 1849.
Caskie was elected a Democrat to the United States House of Representatives in 1850, serving from 1851 to 1859. After being unsuccessful for reelection in 1858, he resumed practicing law until his death in Richmond, Virginia on December 16, 1869. He was interred there in Hollywood Cemetery.