| Honorific-Prefix: | The Hon |
| John O'Keefe | |
| Constituency Am1: | Chillagoe |
| Assembly1: | Queensland Legislative |
| Term Start1: | 16 January 1926 |
| Term End1: | 11 May 1929 |
| Predecessor1: | Ted Theodore |
| Successor1: | Ernest Atherton |
| Constituency Am2: | Cairns |
| Assembly2: | Queensland Legislative |
| Term Start2: | 10 May 1930 |
| Term End2: | 27 January 1942 |
| Predecessor2: | William McCormack |
| Successor2: | Lou Barnes |
| Birth Date: | 11 January 1880 |
| Birth Place: | Gin Gin, Queensland, Australia |
| Death Place: | Brisbane, Queensland, Australia |
| Restingplace: | Nudgee Cemetery |
| Birthname: | John O'Keefe |
| Nationality: | Australian |
| Party: | Labor |
| Spouse: | Lydia Adelaide Dargen (m.1918 d.1947) |
| Occupation: | Drover, Company director |
John O'Keefe (11 January 1880 - 27 January 1942) was an Australian politician. He was a Labor member of the Legislative Assembly of Queensland, representing Chillagoe from 1926 to 1929 and Cairns from 1930 to 1942. He was Attorney-General from 1940 to 1941.[1]
O'Keefe died in office[1] in 1942 and following his funeral at St Stephen's Cathedral was buried in Nudgee Cemetery.[2]