| John O'Keefe | |
| Office: | Member of Parliament for Dungarvan |
| Term Start: | 31 January 1874 |
| Term End: | 10 June 1877 |
| Predecessor: | Henry Matthews |
| Successor: | Frank Hugh O'Donnell |
| Birth Date: | 1827 |
| Death Date: | 10 June 1877 |
| Nationality: | Irish |
| Party: | Home Rule League |
John O'Keefe (1827 – 10 June 1877) was an Irish Home Rule League politician.
He sat as Home Rule Member of Parliament (MP) for Dungarvan in 1874 until his death at age 49 in 1877.[1] He was expelled from the Home Rule League in February 1877 for having supported the Liberal Frederick Lehmann against the Home Rule candidate James Delahunty at the parliamentary by-election for County Waterford in January 1877.[2]