| John Mastrangelo | |
| Number: | 75 (college) 66 (professional) |
| Position: | Guard / Tackle |
| Birth Date: | 10 March 1926 |
| Birth Place: | Vandergrift, Pennsylvania, U.S. |
| Death Place: | Vandergrift, Pennsylvania, U.S. |
| Height Ft: | 6 |
| Height In: | 1 |
| Weight Lbs: | 228 |
| High School: | Vandergrift (PA) |
| College: | Notre Dame |
| Draftyear: | 1947 |
| Draftround: | 3 |
| Draftpick: | 16 |
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| Pfr: | M/MastJo20 |
John Battista Mastrangelo (March 10, 1926 – October 2, 1987) was a professional football player in the National Football League (NFL). He made his NFL debut in 1947 with the Pittsburgh Steelers. He played in the NFL for 4 years, playing for the Steelers, New York Yankees (AAFC) and New York Giants over the course of his career.
Prior to joining the NFL, Mastrangelo played college football at the University of Notre Dame where he received All-American honors. He also played in the College All-Star Game in 1947.