| John Jairo Tréllez | |
| Fullname: | John Jairo Trellez Valencia |
| Birth Date: | 29 April 1968 |
| Birth Place: | Turbo, Colombia |
| Position: | Striker |
| Clubs1: | Atlético Nacional |
| Clubs2: | FC Zürich |
| Clubs3: | Atlético Nacional |
| Clubs4: | Boca Juniors |
| Clubs5: | EC Juventude |
| Clubs6: | Al-Hilal |
| Clubs7: | Dallas Burn |
| Clubs8: | Zhejiang Greentown |
| Clubs9: | Bajo Cauca |
| Years1: | 1985–1989 |
| Years2: | 1989–1991 |
| Years3: | 1991–1994 |
| Years4: | 1994 |
| Years5: | 1995–1996 |
| Years6: | 1997–1998 |
| Years7: | 1999 |
| Years8: | 2001–2004 |
| Years9: | 2005–2006 |
| Caps2: | 33 |
| Caps4: | 16 |
| Caps5: | 86 |
| Caps7: | 17 |
| Goals2: | 12 |
| Goals4: | 3 |
| Goals5: | 18 |
| Goals7: | 3 |
| Nationalyears1: | 1989–1994 |
| Nationalteam1: | Colombia |
| Nationalcaps1: | 24 |
| Nationalgoals1: | 3 |
John Jairo Tréllez Valencia (pronounced as /es-419/; born 29 April 1968) is a retired Colombian footballer. A striker, he played most of his career with Atlético Nacional of Medellín. He has a son, also a striker, Santiago Tréllez.
Tréllez was born in Turbo, Antioquia, and started playing for Atlético Nacional in 1985. He scored his first goal as professional the same day the debuted against Cúcuta Deportivo. With Atlético Nacional Tréllez scored a total of 116 goals, 14 of which were against Independiente Medellín, Atlético Nacional's eternal rivals. In 1992, he became the top goal scorer in Colombia with 25 goals, becoming the first Colombian to become the league's goal scorer for Atlético Nacional. In 1994, Tréllez became the first Colombian to ever play for Boca Juniors of Argentina, where he scored two goals in 19 games, in all competitions.
At the international level, Tréllez also played two seasons for FC Zürich and then played in the United States for the Dallas Burn.