| John Hofford | |
| Position: | Pitcher |
| Bats: | Unknown |
| Throws: | Unknown |
| Birth Date: | May 25, 1863 |
| Birth Place: | Philadelphia |
| Death Place: | Philadelphia |
| Debutleague: | MLB |
| Debutdate: | September 26 |
| Debutyear: | 1885 |
| Debutteam: | Pittsburgh Alleghenys |
| Finalleague: | MLB |
| Finaldate: | July 24 |
| Finalyear: | 1886 |
| Finalteam: | Pittsburgh Alleghenys |
| Statleague: | MLB |
| Stat1label: | Win–loss record |
| Stat1value: | 3–9 |
| Stat2label: | Earned run average |
| Stat2value: | 4.16 |
| Stat3label: | Strikeouts |
| Stat3value: | 46 |
| Teams: |
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John William Hofford (May 25, 1863 – December 16, 1915) was an American professional baseball player who was a pitcher in the major leagues for the 1885–86 Pittsburgh Alleghenys. He played minor league baseball until 1896.