| John H. Druffel | |
| Office: | Senior Judge of the United States District Court for the Southern District of Ohio |
| Term Start: | September 30, 1961 |
| Term End: | May 16, 1967 |
| Office1: | Judge of the United States District Court for the Southern District of Ohio |
| Term Start1: | September 22, 1937 |
| Term End1: | September 30, 1961 |
| Appointer1: | Franklin D. Roosevelt |
| Predecessor1: | Seat established by 50 Stat. 805 |
| Successor1: | Seat abolished |
| Birth Name: | John H. Druffel |
| Birth Date: | 6 February 1886 |
| Birth Place: | Cincinnati, Ohio |
| Education: | Salmon P. Chase College of Law |
John H. Druffel (February 6, 1886 – May 16, 1967) was a United States district judge of the United States District Court for the Southern District of Ohio.
Born in Cincinnati, Ohio, Druffel attended the YMCA Law School (then located in Cincinnati, now the Salmon P. Chase College of Law at Northern Kentucky University) in 1911. He was in private practice in Cincinnati from 1912 to 1932. He was Vice Mayor and a member of the Cincinnati City Council from 1929 to 1932. He was a Judge of the Court of Common Pleas of Hamilton County, Ohio from 1933 to 1937.
On September 22, 1937, Druffel received a recess appointment from President Franklin D. Roosevelt to a new seat on the United States District Court for the Southern District of Ohio created by . Formally nominated to the same seat by President Roosevelt on November 16, 1937, he was confirmed by the United States Senate on December 8, 1937, and received his commission on December 14, 1937. He assumed senior status on September 30, 1961, serving in that capacity until his death on May 16, 1967.