| John Graham | |
| Office1: | United States Minister to Portugal |
| President1: | James Monroe |
| Term Start1: | June 24, 1819 |
| Term End1: | June 13, 1820 |
| Predecessor1: | Thomas Sumter Jr. |
| Successor1: | John James Appleton |
| Office2: | United States Secretary of State |
| Status2: | Acting |
| President2: | James Monroe |
| Term Start2: | March 4, 1817 |
| Term End2: | March 9, 1817 |
| Predecessor2: | James Monroe |
| Successor2: | Richard Rush |
| Office3: | Chief Clerk of the United States Department of State |
| Leader3: | James Madison Robert Smith James Monroe |
| Term Start3: | July 1, 1807 |
| Term End3: | July 18, 1817 |
| Predecessor3: | Jacob Wagner |
| Successor3: | Daniel Brent |
| Birth Place: | Dumfries, Virginia, British America |
| Death Place: | Washington, D.C., U.S. |
| Education: | Columbia University |
John Graham (1774 – August 6, 1820) was an American politician and diplomat. He was born in Dumfries, Virginia, and graduated from Columbia University in 1790. He moved to Kentucky and served in the Kentucky legislature.
From 1801 to 1803 he served as secretary and chargé d'affaires in the U.S. legation to Spain.
Graham was chief clerk of the State Department from 1807 to 1817 and as such was acting United States Secretary of State for five days, from March 4 to March 9, 1817, at the start of the administration of President James Monroe.[1] Along with Caesar Augustus Rodney and Theodorick Bland, Graham was selected by Monroe in 1817 as one of three commissioners for a special diplomatic mission to South America, the South American Commission of 1817-1818.[2] He served as the U.S. Minister to Portugal at Rio de Janeiro from June 24, 1819, to June 13, 1820.
He died in Washington, D.C., on August 6, 1820. His brother, George Graham, was acting Secretary of War under Presidents Madison and Monroe.