John F. Kurtzke Explained
John Francis Kurtzke (September 14, 1926 – December 1, 2015) was a neuroepidemiologist and Professor of Neurology at Georgetown University who is best known for his creation of the Expanded Disability Status Scale and for his research on multiple sclerosis (MS).[1] After graduating from Cornell University Medical College in 1952, Dr. Kurtzke started his career in the field of Neurology as Chief of the Neurology Service at the Veteran's Affairs (VA) Medical Centers in Coatesville, Pennsylvania, from 1956 to 1963, and then in Washington, DC, from 1963 to 1995, where he became Professor of Neurology at Georgetown University. At the time of his death, he held the title of Professor Emeritus at Georgetown University.
Most of his work dealt with multiple sclerosis (MS). In particular, Dr Kurtzke is widely known for his Expanded Disability Status Scale or EDSS (a method of quantifying disability in multiple sclerosis)[2] and for his pioneering work in the field of neuroepidemiology, a branch of epidemiology he helped to establish in 1967 with Dr. Len Kurland and Dr. Milton Alter.[3]
He was a leading world expert on geographical patterns of prevalence of multiple sclerosis.[4] [5] [6] Kurtzke's results have played a major role in promoting the study of the viral component of MS susceptibility.[7]
The author of more than 200 peer-reviewed articles,[8] [9] [10] he has received several awards including the 1999 Charcot Award by the Multiple Sclerosis International Federation[11] and the 1997 Dystel prize for MS research awarded by the American Academy of Neurology.[12]
In 2009, the Consortium of Multiple Sclerosis Centers (CMSC) and the American Academy of Neurology Foundation (AANF) have created the John F. Kurtzke, MD, FAAN, Clinician-Scientist Development Three-Year Award, a jointly-sponsored fellowship in multiple sclerosis research, "to honor the contributions of Dr. Kurtzke and inspire new MS healthcare professionals to follow in his path."[13]
Like Klaus Lauer,[14] J. Kurtzke has dedicated a large part of his work to the study of MS in the Faroe Islands, with extensive studies dealing with the British occupation of the islands,[15] [16] [17] [18] [19] starting what the New York Times called the MS "medical detective story".[20] He died on December 1, 2015.[21]
External links
- Confavreux C . An unchanging man faced with changing times . Brain . 135 . Pt 6 . 1663–5 . June 2012 . 22628387 . 10.1093/brain/aws135. free .
- Feigin V, Kurtzke JF, Korczyn A, Beghi E, Brown A . Bridging the gap between experimental and non-experimental neuroepidemiology, and ultimately - between neuroepidemiological research and practice: round table discussion at the First International Congress on Clinical Neurology and Epidemiology . Neuroepidemiology . 33 . 4 . 296–304 . 2009 . 20443239 . 10.1159/000252942. free .
- Kurtzke JF, Hyllested K . Multiple sclerosis in the Faroe Islands: I. Clinical and epidemiological features . Annals of Neurology . 5 . 1 . 6–21 . January 1979 . 371519 . 10.1002/ana.410050104. 8067353 .
- portrait by E. Granieri. Once on page, press "look inside" icon
- Kurtzke JF, Hyllested K, Arbuckle JD, etal . Multiple sclerosis in the Faroe Islands. IV. The lack of a relationship between canine distemper and the epidemics of MS . Acta Neurologica Scandinavica . 78 . 6 . 484–500 . December 1988 . 3223236 . 10.1111/j.1600-0404.1988.tb03692.x. 12249094 . free .
- Audio podcast and transcript of interview by Consortium of MS centers
- Kurtzke JF . No creative medical science without humor . Journal of Clinical Epidemiology . 55 . 12 . 1214–7 . December 2002 . 12547452 . 10.1016/S0895-4356(02)00530-9.
- Kurtzke JF . Epidemiology and etiology of multiple sclerosis . Physical Medicine and Rehabilitation Clinics of North America . 16 . 2 . 327–49 . May 2005 . 15893675 . 10.1016/j.pmr.2005.01.013.
- Kurtzke JF, Hyllested K, Heltberg A . Multiple sclerosis in the Faroe Islands: transmission across four epidemics . Acta Neurologica Scandinavica . 91 . 5 . 321–5 . May 1995 . 7639059 . 10.1111/j.1600-0404.1995.tb07015.x. 9230202 . free .
- One of the first papers of Kurtzke (1954)
- Wallin MT, Culpepper WJ, Coffman P, etal . The Gulf War era multiple sclerosis cohort: age and incidence rates by race, sex and service . Brain . 135 . Pt 6 . 1778–85 . June 2012 . 22628389 . 10.1093/brain/aws099. free .
- Kurtzke JF . Epidemiology in multiple sclerosis: a pilgrim's progress . Brain . 136 . Pt 9 . 2904–17 . September 2013 . 23983034 . 10.1093/brain/awt220. free .
- Börü UT, Taşdemir M, Güler N, etal . Prevalence of multiple sclerosis: door-to-door survey in three rural areas of coastal Black Sea regions of Turkey . Neuroepidemiology . 37 . 3–4 . 231–5 . 2011 . 22133733 . 10.1159/000334316. 27788896 .
- Kurtzke JF . Multiple sclerosis in time and space--geographic clues to cause . Journal of Neurovirology . 6 . S134–40 . May 2000 . Suppl 2 . 10871801.
- Kurtzke JF . On the prevalence of multiple sclerosis in Serbia . Neuroepidemiology . 37 . 2 . 107–8 . 2011 . 21921644 . 10.1159/000331234. free .
- Kurtzke JF, Hyllested K . Validity of the epidemics of multiple sclerosis in the Faroe Islands . Neuroepidemiology . 7 . 4 . 190–227 . 1988 . 3264056 . 10.1159/000110154.
- Boström I, Callander M, Kurtzke JF, Landtblom AM . High prevalence of multiple sclerosis in the Swedish county of Värmland . Multiple Sclerosis (Houndmills, Basingstoke, England) . 15 . 11 . 1253–62 . November 2009 . 19805442 . 10.1177/1352458509345909. 33048153 .
- Wallin MT, Page WF, Kurtzke JF . Migration and multiple sclerosis in Alaskan military veterans . Journal of Neurology . 256 . 9 . 1413–7 . September 2009 . 19377862 . 10.1007/s00415-009-5123-5. 19863896 .
- Cabrera-Gómez JA, Kurtzke JF, González-Quevedo A, Lara-Rodríguez R . An epidemiological study of neuromyelitis optica in Cuba . Journal of Neurology . 256 . 1 . 35–44 . January 2009 . 19224310 . 10.1007/s00415-009-0009-0. 26947631 .
- Kurtzke JF . Epidemiologic evidence for multiple sclerosis as an infection . Clinical Microbiology Reviews . 6 . 4 . 382–427 . October 1993 . 8269393 . 358295 . 10.1128/CMR.6.4.382.
- Kurtzke JF . Historical and clinical perspectives of the expanded disability status scale . Neuroepidemiology . 31 . 1 . 1–9 . 2008 . 18535394 . 10.1159/000136645. free .
- Wallin MT, Page WF, Kurtzke JF . Multiple sclerosis in US veterans of the Vietnam era and later military service: race, sex, and geography . Annals of Neurology . 55 . 1 . 65–71 . January 2004 . 14705113 . 10.1002/ana.10788. 11105223 .
- Kurtzke JF, Heltberg A . Multiple sclerosis in the Faroe Islands: an epitome . Journal of Clinical Epidemiology . 54 . 1 . 1–22 . January 2001 . 11165464 . 10.1016/S0895-4356(00)00268-7.
- Rasmussen HB, Kvinesdal BB, Clausen J . Seroreactivity to human T cell leukemia/lymphoma virus type 1 and related retroviruses in multiple sclerosis patients from Denmark and the Faroes . Acta Neurologica Scandinavica . 86 . 1 . 91–4 . July 1992 . 1325731 . 10.1111/j.1600-0404.1992.tb08061.x. 21134064 . free .
- Kurtzke JF, Hyllested K . Multiple sclerosis in the Faroe Islands. II. Clinical update, transmission, and the nature of MS . Neurology . 36 . 3 . 307–28 . March 1986 . 3951697 . 10.1212/wnl.36.3.307. 24993626 .
- Kurtzke JF, Hyllested K . Multiple sclerosis in the Faroes: 1. Clinical and epidemiologic features . Transactions of the American Neurological Association . 103 . 201–5 . 1978 . 757058.
Notes and References
- News: JOHN KURTZKE Obituary - Falls Church, VA - The Washington Post. The Washington Post. 21 December 2015.
- Kurtzke JF . Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) . Neurology . 33 . 11 . 1444–52 . November 1983 . 6685237 . 10.1212/WNL.33.11.1444. free .
- Kelley . Roger E. . Azizi . S. Ausim . Milton Alter, MD, PhD (1929–2016) . Neurology . 87 . 10 . September 2016 . 976–977 . 10.1212/WNL.0000000000003074. 79255558 .
- Web site: Archived copy . 2013-06-03 . 2016-03-04 . https://web.archive.org/web/20160304030249/http://www.direct-ms.org/pdf/GeneralInfoMS/CompstonStory.pdf . dead .
- Kurtzke . John F. . 1977 . Geography in multiple sclerosis . 10.1007/BF00312546 . 215 . 1 . Journal of Neurology . 1–26 . 67196. 10.1.1.411.475 . 19914730 .
- Book: Kurtzke, John F. . Field . E.J. . Multiple Sclerosis: A Critical Conspectus . 1977 . Multiple sclerosis from an epidemiological viewpoint . 10.1007/978-94-010-9534-1_4 . 83–142 . 978-94-010-9536-5.
- Trigger, pathogen, or bystander: the complex nexus linking Epstein- Barr virus and multiple sclerosis.. Owens GP, Bennett JL. 22685062. 10.1177/1352458512448109. 18. 9. 2012. Mult. Scler.. 1204–8. 5135482.
- Kurtzke . John F. . 2006 . An epidemiologic view of the etiology of multiple sclerosis . Archivos de Neurociencias . 11 . 2 . 90–99.
- Web site: Archived copy . 2014-09-15 . https://web.archive.org/web/20150226172435/http://www.va.gov/MS/Professionals/research/KurtzkeMonograph.pdf . 2015-02-26 . dead .
- Web site: Archived copy . 2014-09-15 . https://web.archive.org/web/20150402095327/http://www.va.gov/MS/Professionals/research/Kurtzke_Slides.pdf . 2015-04-02 . dead .
- Web site: World of MS - Research - the Charcot Award . 2022-05-29 . 2013-06-20 . https://archive.today/20130620000418/http://rm2-msif-live.torchboxapps.com/en/research/msif_research_awards/the_charcot.html . bot: unknown .
- http://www.nationalmssociety.org/ms-clinical-care-network/researchers/get-funding/john-dystel-prize/index.aspx{{full citation needed|date=August 2014}}
- Web site: Archived copy . 2013-06-03 . 2016-03-04 . https://web.archive.org/web/20160304040738/http://www.cmscfoundation.org/news2/press-releases/46-press-releases/125-new-multiple-sclerosis-fellowship-created-in-the-name-of-pioneer-neuroepidemiologist-john-f-kurtzke-md-faan . dead .
- Lauer K . Multiple sclerosis in relation to industrial and commercial activities in the Faroe Islands . Neuroepidemiology . 7 . 4 . 228–33 . 1988 . 3264057 . 10.1159/000110155.
- Kurtzke JF, Hyllested K . Multiple sclerosis in the Faroe Islands: I. Clinical and epidemiological features . Annals of Neurology . 5 . 1 . 6–21 . January 1979 . 371519 . 10.1002/ana.410050104. 8067353 .
- Kurtzke JF, Hyllested K . Validity of the epidemics of multiple sclerosis in the Faroe Islands . Neuroepidemiology . 7 . 4 . 190–227 . 1988 . 3264056 . 10.1159/000110154.
- Kurtzke . J. F. . Hyllested . K. . Heltberg . A. . Olsen . Á. . September 1993 . Multiple sclerosis in the Faroe Islands. 5. . 10.1111/j.1600-0404.1993.tb04211.x . 88 . 3 . Acta Neurologica Scandinavica . 161–173 . 8256551. 39114097 .
- Kurtzke . John F. . Hyllested . Kay . Multiple Sclerosis in the Faroe Islands and the Lack of Protection by Exposure in Infancy . Neuroepidemiology . 11 . 2 . 1992 . 90–99 . 10.1159/000110917 . 1495579.
- Kurtzke . John F. . Hyllested . Kay . March 1986 . Multiple sclerosis in the Faroe Islands . Neurology . 36 . 3 . 307–328 . 10.1212/WNL.36.3.307 . 3951697. 24993626 .
- Web site: Brody . Jane E. . MS: A Medical Detective Story . 22 June 1982 . The New York Times . 21 December 2015.
- Web site: National MS Society Mourns the Passing of Dr. John Kurtzke. National Multiple Sclerosis Society. 21 December 2015. dead. https://web.archive.org/web/20151222155508/http://www.nationalmssociety.org/About-the-Society/News/National-MS-Society-Mourns-the-Passing-of-Dr-John. 22 December 2015.