| John E. Sanford | |
| Birth Date: | 22 November 1830 |
| Birth Place: | Dennis, Massachusetts |
| Death Place: | Taunton, Massachusetts |
| Spouse: | Emily J. White, married December 10, 1856 |
| Speaker of the Massachusetts House of Representatives | |
| Term Start: | 1872 |
| Term End: | 1875 |
| Title3: | 9th Insurance Commissioner of Massachusetts |
| Term Start3: | June 29, 1866 |
| Term End3: | November 1, 1869 |
| Predecessor3: | George W. Sargent |
| Title4: | Chairman of the Massachusetts Board of Railroad Commissioners |
John Elliot Sanford (November 22, 1830 – October 11, 1907) was a U.S. politician who served as the ninth Insurance Commissioner of Massachusetts from June 29, 1866, to November 1, 1869; as Chairman of the Massachusetts Board of Railroad Commissioners; and, from 1872 to 1875, as the Speaker of the Massachusetts House of Representatives.[1]