| John E. Cole | |
| Birth Date: | 1942 8, df=yes |
| Birth Place: | Toronto, Ontario |
| Riding: | York—Simcoe |
| Predecessor: | Riding established |
| Successor: | Karen Kraft Sloan |
| Term Start: | 1988 |
| Term End: | 1993 |
| Profession: | optometrist |
| Party: | Progressive Conservative |
John E. Cole (born 4 August 1942) was a Progressive Conservative party member of the House of Commons of Canada. He was an optometrist by career.
He represented the Ontario riding of York—Simcoe where he was elected in the 1988 federal election and served in the 34th Canadian Parliament. Cole left federal politics in the 1993 federal election after his loss to Karen Kraft Sloan of the Liberal party.