| State: | OR |
| Type: | Hwy |
| Route: | 5 |
| Map Custom: | yes |
| Map Notes: | John Day Highway highlighted in red |
| Length Mi: | 270.14 |
| Allocation: | |
| Established: | 1917 |
| Direction A: | West |
| Terminus A: | near Arlington |
| Junction: |
|
| Direction B: | East |
| Terminus B: | in Vale |
| Counties: | Gilliam, Wheeler, Grant, Baker, Malheur |
John Day Highway No. 5 is a highway in eastern Oregon. It comprises Oregon Route 19 (OR 19) and U.S. Route 26 (US 26), as well as short segments of OR 206, OR 207, and US 395.
The John Day Highway begins at an interchange with Interstate 84, 1miles north of Arlington. It follows OR 19 southward for about 76miles, through the cities of Condon and Fossil, where it meets with OR 207 at Service Creek. Here the highway turns eastward and follows OR 207 for 16miles to Spray. At Spray, it splits from OR 207 and goes southward. The highway passes the community of Kimberly, through the John Day Fossil Beds National Monument, and meets up with U.S. 26. The highway then follows US 26 eastward, through the communities of Dayville, Mount Vernon, Prairie City, Unity, Ironside, and Jamieson. The John Day Highway ends at Vale.
The John Day Highway from Fossil to Austin Junction is also a part of the Journey Through Time Scenic Byway,[1] an Oregon state byway.