| John Ayshford Wise | |
| Office: | Member of Parliament for Stafford |
| Term Start: | 8 July 1852 |
| Term End: | 30 August 1860 |
| Alongside: | Thomas Salt (1859–1860) Charles Chetwynd-Talbot (1857–1859) Arthur Otway (1852–1857) |
| Predecessor: | David Urquhart Thomas Sidney |
| Successor: | Thomas Sidney Thomas Salt |
| Birth Date: | 1810 |
| Nationality: | British |
| Party: | Liberal |
| Otherparty: | Whig |
John Ayshford Wise (1810 – 9 September 1865)[1] was a British Liberal and Whig politician.[2]
Wise was first elected Whig MP for Stafford at the 1852 general election and, becoming a Liberal in 1859, held the seat until 1860, when he resigned by becoming Steward of the Manor of Hempholme, causing a by-election.[3]