Joffroy's sign explained

Differential:Graves disease

Joffroy's sign is a clinical sign in which there is a lack of wrinkling of the forehead when a patient looks up with the head bent forwards.[1] It occurs in patients with exophthalmos in Graves disease.[2]

The sign is named after Alexis Joffroy.

Notes and References

  1. Woods. Alan. The Ocular Changes of Primary Diffuse Toxic Goitre A Review. Medicine. May 1946. 25. 2. 113–154. 10.1097/00005792-194605000-00002. free.
  2. Means. JH. The Nature of Graves' Disease With Special Reference to Its Ophthalmic Component. American Journal of the Medical Sciences. January 1944. 207. 1. 1–18. 10.1097/00000441-194401000-00001.

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