Joachim Lingner Explained

Nationality:Swiss
Occupation:Cell biology
Boards:
Joachim Lingner
Website:https://www.epfl.ch/labs/lingner-lab/
Alma Mater:University of Basel
Discipline:Cell biology
Workplaces:École Polytechnique Fédérale de Lausanne (EPFL)
Main Interests:
Awards:
  • Friedrich Miescher Prize
  • ERC Advanced Investigator Award

Joachim Lingner (born 1962) is a Swiss molecular biologist. He holds the professorship for life sciences and leads the Lingner Lab[1] at the École Polytechnique Fédérale de Lausanne (EPFL).

Career

Lingner obtained his PhD from the Biozentrum of the University of Basel in 1992.[2] In 1993 he joined the Howard Hughes Medical Institute at University of Colorado at Boulder for postdoctoral studies under the supervision of Thomas Cech.[3] He then joined Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, Switzerland, first as a junior group leader in 1997 and became senior group leader in 2002. In 2005 he was appointed as associate professor at EPF Lausanne. Since 2009, Lingner is a full professor at EPF Lausanne.[4] [5]

Research

The Lingner Lab studies of the structure, function and maintenance of telomeres, the nucleoprotein complexes at the ends of eukaryotic chromosomes that enable chromosome stability and that regulate cellular lifespan. They elucidated how telomere shortening is counteracted by the telomerase enzyme that renders cancer cells immortal.[6] [7] The lab discovered that telomeres are transcribed into telomeric repeat containing RNA (TERRA),[8] which in turn regulates the telomeric chromatin structure and telomere maintenance by telomerase and homology directed repair.[9] [10] Finally, they developed technologies to uncover the changes that occur in the telomeric proteome during aging and disease including cancer.[11] [12]

Awards and recognitions

Lingner obtained the Friedrich Miescher Prize (2002),[13] was elected as an EMBO member (2005),[14] and received an ERC advanced investigator award (2008),[15] and is a member of the Academia Europaea (2020).[16]

He serves as a member of the scientific advisory board in the Center of Integrative Genomics (CIG) of the University of Lausanne,[17] and has been a member of ERC starting grant review panel.[18]

Selected works

References

  1. Web site: LINGNER LAB. 2020-09-02. www.epfl.ch. en-GB.
  2. Lingner. Joachim. Kellermann. Josef. Keller. Walter. 1991-12-12. Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiae. Nature. en. 354. 6353. 496–498. 10.1038/354496a0. 1840648. 1991Natur.354..496L. 2713293. 0028-0836.
  3. Lingner. J.. 1997-04-25. Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase. Science. 276. 5312. 561–567. 10.1126/science.276.5312.561. 9110970.
  4. Teixeira. M.Teresa. Arneric. Milica. Sperisen. Peter. Lingner. Joachim. April 2004. Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States. Cell. en. 117. 3. 323–335. 10.1016/S0092-8674(04)00334-4. 15109493. 18179591. free.
  5. Chen. Liuh-Yow. Redon. Sophie. Lingner. Joachim. August 2012. The human CST complex is a terminator of telomerase activity. Nature. en. 488. 7412. 540–544. 10.1038/nature11269. 22763445. 2012Natur.488..540C. 4412583. 0028-0836.
  6. Teixeira. M.Teresa. Arneric. Milica. Sperisen. Peter. Lingner. Joachim. 2004-04-30. Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States. Cell. en. 117. 3. 323–335. 10.1016/S0092-8674(04)00334-4. 15109493. 18179591. free.
  7. Chen. Liuh-Yow. Redon. Sophie. Lingner. Joachim. 2012-07-04. The human CST complex is a terminator of telomerase activity. Nature. en. 488. 7412. 540–544. 10.1038/nature11269. 22763445. 2012Natur.488..540C. 4412583. 0028-0836.
  8. Azzalin. Claus M.. Lingner. Joachim. 2007-08-30. Damage control. Nature. en. 448. 7157. 1001–1002. 10.1038/4481001a. 17728746. 37239103. 1476-4687.
  9. Porro. Antonio. Feuerhahn. Sascha. Lingner. Joachim. 2014-02-27. TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres. Cell Reports. en. 6. 4. 765–776. 10.1016/j.celrep.2014.01.022. 24529708. free.
  10. Vančevska. Aleksandra. Ahmed. Wareed. Pfeiffer. Verena. Feretzaki. Marianna. Boulton. Simon J. Lingner. Joachim. 2020-04-01. SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres. The EMBO Journal. 39. 7. e102668. 10.15252/embj.2019102668. 0261-4189. 7110143. 32080884.
  11. Grolimund. Larissa. Aeby. Eric. Hamelin. Romain. Armand. Florence. Chiappe. Diego. Moniatte. Marc. Lingner. Joachim. 2013-11-25. A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nature Communications. en. 4. 1. 2848. 10.1038/ncomms3848. 24270157. 2013NatCo...4.2848G. 2041-1723. free.
  12. Ahmed. Wareed. Lingner. Joachim. 2017-12-04. Impact of oxidative stress on telomere biology. Differentiation. en. 99. 21–27. 10.1016/j.diff.2017.12.002. 29274896. free.
  13. Web site: Awards - Funding - LS². 2020-09-02. www.ls2.ch.
  14. Web site: Katja. Find a Member. 2020-09-02. EMBO. en-gb.
  15. https://erc.europa.eu/sites/default/files/content/selection_panel/advanced_grant_2008.pdf
  16. Web site: List all members by country.
  17. Web site: Scientific Advisory Committee. 2020-09-02. www.unil.ch. en.
  18. https://erc.europa.eu/sites/default/files/document/file/erc_2018_stg_panel_members.pdf

External links

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