| Jiquilisco | |
| Settlement Type: | City and municipality |
| Pushpin Map: | El Salvador |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in El Salvador |
| Subdivision Type: | Country |
| Subdivision Name: |  El Salvador |
| Subdivision Type1: | Department |
| Subdivision Name1: | Usulután Department |
| Government Type: | GANA |
| Leader Title: | Mayor |
| Leader Name: | Loida Eunice Loza de Perez |
| Unit Pref: | Imperial |
| Area Total Km2: | 429.99 |
| Population As Of: | 2007 |
| Population Total: | 47,784 |
| Population Blank1 Title: | Ethnicities |
| Timezone: | UTC-6 |
| Coordinates: | 13.3167°N -88.5833°W |
| Elevation M: | 44 |
Jiquilisco is a city and municipality in the Usulután department of El Salvador.
The local football clubs are named C.D. Topiltzín and A.D. El Tercio and they currently play in the Salvadoran Second and Third Division respectively.