| Jimmy Isaac | |
| Fullname: | James Isaac |
| Birth Date: | 23 October 1916 |
| Birth Place: | Cramlington, England |
| Death Date: | December 1993 (aged 77) |
| Death Place: | England |
| Position: | Striker |
| Years1: | 1936–1939 |
| Years2: | 1946–1947 |
| Years3: | 1947–1949 |
| Clubs3: | Hartlepools United |
| Caps1: | 33 |
| Caps2: | 24 |
| Caps3: | 56 |
| Goals1: | 8 |
| Goals2: | 3 |
| Goals3: | 9 |
James Isaac (23 October 1916 – December 1993) was a professional footballer, who played for Huddersfield Town, Bradford City and Hartlepools United. He was born in Cramlington, Northumberland.