| Jelena Despotović | |
| Birth Date: | 30 April 1994 |
| Birth Place: | Podgorica, Montenegro, FR Yugoslavia |
| Nationality: | Montenegrin |
| Height: | 1.83 m |
| Position: | Left back |
| Currentclub: | Budućnost Podgorica |
| Clubnumber: | 80 |
| Years1: | 2010–2011 |
| Clubs1: | Budućnost Podgorica |
| Years2: | 2011–2012 |
| Years3: | 2012–2015 |
| Clubs3: | Budućnost Podgorica |
| Years4: | 2015–2017 |
| Clubs4: | Debreceni VSC |
| Years5: | 2017 |
| Clubs5: | RK Krim |
| Years6: | 2017–2021 |
| Clubs6: | Debreceni VSC |
| Years7: | 2021–2023 |
| Clubs7: | Győri ETO KC |
| Years8: | 2023 |
| Clubs8: | Ferencvárosi TC |
| Years9: | 2023– |
| Clubs9: | Budućnost Podgorica |
| Nationalyears1: | 2012– |
| Nationalteam1: | Montenegro |
| Nationalcaps1: | 112 |
| Nationalgoals1: | 178 |
Jelena Despotović (born 30 April 1994) is a Montenegrin handball player[1] for Budućnost Podgorica and the Montenegrin national team.[2]
She won the EHF Champions League trophy with Budućnost in the 2014–15 season.
Her partner is Bogdan Radivojević handball player. Their daughter Helena was born in August 2022.[3]