Jean Pieters Explained

Jean Pieters
Nationality:Dutch
Field:Biochemistry
Work Institutions:University of Leuven, Maastricht University, European Molecular Biology Laboratory, Netherlands Cancer Institute in Amsterdam, Basel Institute for Immunology, Biozentrum University of Basel

Jean Pieters is a Dutch biochemist and Professor at the Biozentrum of the University of Basel, Switzerland.

Life

Jean Pieters studied biochemistry and microbiology at the University of Leuven in Belgium. After completing his doctorate at Maastricht University, the Netherlands, he joined the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1989 as a postdoctoral fellow in Bernhard Dobberstein’s laboratory. From 1992 until 1995 Jean Pieters researched at the Netherlands Cancer Institute in Amsterdam as a junior group leader. In 1996 he was recruited to the Basel Institute for Immunology and in 2002 appointed to the Biozentrum at the University of Basel.[1]

Work

Jean Pieters investigates the role of coronin proteins in activating cellular signal transduction processes. Coronin proteins are widely distributed in the eukaryotic kingdom and conserved from yeast to man. One of the most conserved members of this protein family, mammalian coronin 1, was originally discovered in his laboratory as a host factor responsible for the intracellular survival of pathogenic mycobacteria.[2] Subsequent work from his laboratory showed that coronin proteins regulate diverse physiologic processes including T cell homeostasis,[3] learning and memory [4] and development.[5] More recently, his laboratory showed that coronin 1 signaling plays a crucial role in auto- and alloimmunity [6] [7] [8] and that coronin-mediated signaling underlies the longevity of T cells.[9] Research in his laboratory currently focusses on the role for coronin proteins in the establishment and regulation of cell populations.

Awards and honors

Notable publications

References

  1. https://orcid.org/0000-0002-5284-9757 Orcid profile
  2. 10338208 . 97 . 4 . A coat protein on phagosomes involved in the intracellular survival of mycobacteria . 14 May 1999 . Cell . 435–447. 10.1016/s0092-8674(00)80754-0. Ferrari . G. . Langen . H. . Naito. M. . Pieters. Jean. 18159353. free .
  3. 18345003 . 9 . 4. Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering . April 2008 . Nat Immunol . 424–31 . 10.1038/ni1570 . Mueller . Philipp . Massner . Jan . Jayachandran. Rajesh . Combaluzier . Benoit . Albrecht. Imke . Gatfield . John . Blum . Carmen . Ceredig . Rod . Rodewald . Hans-Reimer . Rolink. Antonius G . Pieters. Jean . 26849229.
  4. 24667537 . 12 . 3 . Coronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signaling . 25 March 2014 . PLOS Biol . 10.1371/journal.pbio.1001820 . Jayachandran . Rajesh . Liu . Xiaolong . Bosedasgupta . Somdeb . Müller . Philipp . Zhang . Chun-Lei . Moshous . Despina . Studer . Vera . Schneider . Jacques . Genoud . Christel . Fossoud . Catherine . Gambino . Frédéric . Khelfaoui . Malik . Müller . Christian . Bartholdi . Deborah . Rossez . Helene . Stiess . Michael . Houbaert . Xander . Jaussi . Rolf . Frey . Daniel . Kammerer . Richard A . Deupi . Xavier . de Villartay . Jean-Pierre . Lüthi . Andreas . Humeau . Yann . Pieters . Jean . e1001820 . 3965382 . free .
  5. 24403600 . 25 . 5. Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A . 25 March 2014 . Mol Biol Cell . 10.1091/mbc.E13-04-0219 . Vinet . Adrien F . Fiedler . Thomas . Studer . Vera . Froquet . Romain . Dardel . Anna . Cosson . Pierre . Pieters . Jean . 688–701 . 3937094 .
  6. 23765056 . 13 . 7. On guard: coronin proteins in innate and adaptive immunity . 13 July 2013 . Nat Rev Immunol . 10.1038/nri3465 . Pieters . Jean . Müller . Philipp . Jayachandran . Rajesh . 510–518 . 38179365 .
  7. 30611611 . 50 . 1 . Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity . 15 January 2019 . Immunity . 10.1016/j.immuni.2018.12.011 . Jayachandran . Rajesh . Gumienny . Aleksandra . Bolinger . Beatrice . Ruehl . Sebastian . Lang . Mathias Jakob . Fucile . Geoffrey . Mazumder . Saumyabrata . Tchang . Vincent . Woischnig . Anne-Kathrin . Stiess . Michael . Kunz . Gabriele . Claudi . Beatrice . Schmaler . Mathias . Siegmund . Kerstin . Li . Jianping . Dertschnig . Simone . Holländer . George . Medina . Eva . Karrer . Urs . Moshous . Despina . Bumann . Dirk . Khanna . Nina . Rossi . Simona W . Pieters . Jean . 152–165.e8 . 58669087 . free . 10033/622367 . free .
  8. 30650379 . 50 . 1 . Coronin-1, King of Alloimmunity . 15 January 2019 . Immunity . 10.1016/j.immuni.2018.12.030 . Ford . Mandy L . 3–5 . 58571940 . free .
  9. 34932374 . 14 . 714 . Suppression of caspase 8 activity by a coronin 1-PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling . 21 December 2021 . Sci Signal . 10.1126/scisignal.abj0057 . Mori . Mayumi . Ruer-Laventie . Julie . Duchemin . Wandrille . Demougin . Philippe . Ndinyanka Fabrice . Tohnyui . Wymann . Matthias P . Pieters . Jean . eabj0057 . 245409202 .
  10. https://www.knaw.nl/en/news/news/nieuw-bestuur-en-nieuwe-leden-knaw Elected Corresponding Member of the Royal Netherlands Academy of Arts and Sciences
  11. Web site: Jean Pieters . https://web.archive.org/web/20200730104407/https://www.knaw.nl/en/members/correspondents/11672 . Royal Netherlands Academy of Arts and Sciences . 30 July 2020.
  12. http://www.swissbiochem.ch/FMA/Awardees.php The Awardees of the Friedrich Miescher-Award
  13. http://www.pfizerforschungspreis.ch/content/pfizerpreis/de/home/prizewinner/2001.html Pfizer Forschungspreis, Preisträger 2001
  14. http://corporate.eppendorf.com/de/unternehmen/wissenschaftliche-awards/european-award Eppendorf Award for Young European Investigators, Past Award Winners

External links

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