| Jean-Louis Margue | |
| Birth Date: | 1952 8, df=yes |
| Position: | defender |
| Years1: | 1968–1983 |
| Clubs1: | Progrès Niederkorn |
| Nationalyears1: | 1975–1979 |
| Nationalteam1: | Luxembourg |
| Nationalcaps1: | 16 |
| Nationalgoals1: | 0 |
Jean-Louis Margue (born 9 August 1952) is a retired Luxembourgian football defender.