| Jean-François Le Grand | |
| Office: | President of the General council of Manche |
| Term Start: | 1998 |
| Term End: | 2015 |
| Predecessor: | Pierre Aguiton |
| Successor: | Philippe Bas |
| Office2: | Member of the French Senate for Manche |
| Term Start2: | 1982 |
| Term End2: | 2011 |
| Successor2: | Philippe Bas |
| Birth Date: | 8 June 1942 |
| Birth Place: | Lessay, France |
| Nationality: | French |
| Party: | Independent |
| Profession: | Veterinarian |
Jean-François Le Grand (pronounced as /fr/; born 8 June 1942 in Lessay, Manche) is a French politician and a former member of the Senate of France. He represented the Manche department as a member of the Union for a Popular Movement Party.