| Jay Difani | |
| Position: | Second baseman |
| Bats: | Right |
| Throws: | Right |
| Birth Date: | 21 December 1922 |
| Birth Place: | Crystal City, Missouri |
| Death Place: | Crystal City, Missouri |
| Debutleague: | MLB |
| Debutdate: | April 23 |
| Debutteam: | Washington Senators |
| Finalleague: | MLB |
| Finaldate: | April 28 |
| Finalteam: | Washington Senators |
| Statleague: | MLB |
| Stat1label: | Batting average |
| Stat1value: | .333 |
| Stat2label: | Home runs |
| Stat2value: | 0 |
| Stat3label: | Runs batted in |
| Stat3value: | 0 |
| Teams: |
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Clarence Joseph "Jay" Difani (December 21, 1922 – December 3, 2003) was an American professional baseball player. He was a second baseman over parts of two seasons (1948–49) with the Washington Senators. For his career, he compiled a .333 batting average with one hit in three at-bats.
An alumnus of the University of Missouri, he was born in and, later, died in Crystal City, Missouri at the age of 80.