| Jatun Mayu | |
| Name Etymology: | Quechua |
| Subdivision Type1: | Country |
| Subdivision Name1: | Bolivia |
| Subdivision Type3: | Region |
| Subdivision Name3: | Chuquisaca Department, Jaime Zudáñez Province |
| Source1 Location: | Icla Municipality |
| Source1 Coordinates: | -19.4075°N -64.6972°W |
| Mouth Location: | Icla Municipality |
| Mouth Coordinates: | -19.3653°N -64.7928°W |
Jatun Mayu (Quechua hatun, jatun great, mayu river, "great river") is a Bolivian river in the Chuquisaca Department, Jaime Zudáñez Province, Icla Municipality. It is a left affluent of the Icla River. It belongs to the watershed of the Pillku Mayu.