Jason Locasale Explained

Jason Locasale
Birth Place:New Jersey, U.S.
Nationality:American
Alma Mater:Rutgers University (B.A.)
Massachusetts Institute of Technology (Ph.D.)
Harvard University (Postdoctoral Fellowship)
Fields:Cancer Research, Metabolism, Metabolomics, Nutrition
Work Institutions:Duke University
Academic Advisors:Lewis C. Cantley

Jason W. Locasale is an American scientist and university professor. His focus is on metabolism.

Education

Locasale graduated summa cum laude from Rutgers University with a dual degree in Chemistry and Physics. While completing his undergraduate degree, he received initial training in research in biochemistry and structural biology under Helen Berman. He earned a Ph.D. from the Massachusetts Institute of Technology. He went on to complete a postdoctoral fellowship at Harvard Medical School under Lewis C. Cantley.[1] [2]

He is currently an associate professor with tenure at Duke University School of Medicine.[3]

Research

Locasale has pioneered the use of methods to study metabolism using primarily liquid chromatography-mass spectrometry (LC-MS),[4] in particular having developed methods to gain insights into numerous biological processes at once.[5] He has made contributions to understanding the role of serine synthesis and one carbon metabolism in cancers,[6] [7] [8] [9] [10] defining the quantitative, mechanistic principles of the Warburg Effect[11] and altered glucose metabolism in cancer,[12] and the role of metabolism in mediating chromatin status and epigenetics.[13] [14] [15] His recent work which has gained widespread public attention[16] [17] [18] [19] has focused on the effects on dietary methionine restriction and diet in general as a therapeutic approach[20] [21] to extend lifespan and shape tumor response to therapy.[22] [23] [24]

His research approaches integrate computational modeling, cell biology, mouse models, and genetic and biochemical experimentation to understand metabolic processes and their contribution to health.[25] Currently, his research is in three interconnected areas: (1) Quantitative biology of metabolism, (2) Dietary interventions and metabolic therapeutics in health and cancer, and (3) The mechanistic basis between the interaction of metabolism and epigenetics.[26]

Awards and recognitions

Locasale is a recipient of the National Institutes of Health Pathway to Independence Award, the Benjamin Trump Award for Excellence in Cancer Research, and the American Cancer Society Research Scholar Award, and the JH Quastell Lectureship at McGill University.[27] He serves on the editorial boards for a number of journals including PLoS Biology, Oncotarget, and Cell Stress,[28] [29] and has served in advisory roles for a number of companies. He has also maintained advisory roles at a number of federal, private and international scientific agencies including the National Institutes of Health, the American Cancer Society, and the Israel Science Foundation. He is also widely accomplished in academic mentoring with students and trainees having received the nation's highest honors at the undergraduate, doctoral, and postdoctorals levels[30] [31] .

Locasale has authored over 150 publications in peer-reviewed journals and numerous textbook chapters and patents. In 2019, he was named one of the most influential researchers of the past 10 years by Web of Science.[32] [33] [34]

Notes and References

  1. Web site: Jason Locasale: Fighting cancer with chemical complexity and collaboration. The Chronicle. 2019-12-01.
  2. Web site: Speaker: Cell Symposia: Metabolites as Signalling Molecules. www.cell-symposia.com. 2019-12-01.
  3. Web site: Jason Locasale Duke School of Medicine. medschool.duke.edu. 2019-12-01.
  4. Liu. Xiaojing. Ser. Zheng. Locasale. Jason W. 2014-02-18. Development and Quantitative Evaluation of a High-Resolution Metabolomics Technology. Analytical Chemistry. 86. 4. 2175–2184. 10.1021/ac403845u. 0003-2700. 3983012. 24410464.
  5. Web site: Cancer Metabolism: A Conversation with Jason Locasale. 2016-11-28. National Cancer Institute. 2019-12-01.
  6. Locasale. Jason W.. August 2013. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nature Reviews Cancer. 13. 8. 572–583. 10.1038/nrc3557. 1474-1768. 3806315. 23822983.
  7. Gao. Xia. Lee. Katie. Reid. Michael A.. Sanderson. Sydney M.. Qiu. Chuping. Li. Siqi. Liu. Juan. Locasale. Jason W.. 2018-03-27. Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism. Cell Reports. 22. 13. 3507–3520. 10.1016/j.celrep.2018.03.017. 2211-1247. 6054483. 29590619.
  8. Locasale. Jason W.. Grassian. Alexandra R.. Melman. Tamar. Lyssiotis. Costas A.. Mattaini. Katherine R.. Bass. Adam J.. Heffron. Gregory. Metallo. Christian M.. Muranen. Taru. Sharfi. Hadar. Sasaki. Atsuo T.. September 2011. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. en. 43. 9. 869–874. 10.1038/ng.890. 21804546. 1546-1718. 3677549.
  9. Reid. Michael A.. Allen. Annamarie E.. Liu. Shiyu. Liberti. Maria V.. Liu. Pei. Liu. Xiaojing. Dai. Ziwei. Gao. Xia. Wang. Qian. Liu. Ying. Lai. Luhua. 2018-12-21. Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism. Nature Communications. en. 9. 1. 5442. 10.1038/s41467-018-07868-6. 30575741. 6303315. 2041-1723. 2018NatCo...9.5442R. free.
  10. Mehrmohamadi. Mahya. Liu. Xiaojing. Shestov. Alexander A.. Locasale. Jason W.. 2014-11-20. Characterization of the Usage of the Serine Metabolic Network in Human Cancer. Cell Reports. en. 9. 4. 1507–1519. 10.1016/j.celrep.2014.10.026. 2211-1247. 25456139. 4317399.
  11. Liberti. Maria V.. Locasale. Jason W.. March 2016. The Warburg Effect: How Does it Benefit Cancer Cells?. Trends in Biochemical Sciences. 41. 3. 211–218. 10.1016/j.tibs.2015.12.001. 0968-0004. 4783224. 26778478.
  12. Liberti. Maria V.. Dai. Ziwei. Wardell. Suzanne E.. Baccile. Joshua A.. Liu. Xiaojing. Gao. Xia. Baldi. Robert. Mehrmohamadi. Mahya. Johnson. Marc O.. Madhukar. Neel S.. Shestov. Alexander A.. 2017-10-03. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metabolism. 26. 4. 648–659.e8. 10.1016/j.cmet.2017.08.017. 1932-7420. 5629112. 28918937.
  13. Mentch. Samantha J.. Mehrmohamadi. Mahya. Huang. Lei. Liu. Xiaojing. Gupta. Diwakar. Mattocks. Dwight. Gómez Padilla. Paola. Ables. Gene. Bamman. Marcas M.. Thalacker-Mercer. Anna E.. Nichenametla. Sailendra N.. 2015-11-03. Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. Cell Metabolism. 22. 5. 861–873. 10.1016/j.cmet.2015.08.024. 1550-4131. 4635069. 26411344.
  14. Web site: High-Throughput Epigenetics Analyses. The Scientist Magazine®. en. 2019-12-08.
  15. Web site: Potentially reversible changes in gene control 'prime' pancreatic cancer cells to spread: Epigenetic changes, not DNA mutations, drive some metastasis. ScienceDaily. en. 2019-12-25.
  16. Web site: How a dietary change might boost cancer therapy. Medical News Today. 4 August 2019 . en. 2019-12-25.
  17. Web site: Vegan diets may help boost cancer treatments. 2019-08-06. KAMR - MyHighPlains.com. en-US. 2019-12-25.
  18. Web site: Going vegan 'really can prevent cancer'. Says. Dyljohbar. 2019-07-31. The London Economic. en-GB. 2019-12-28.
  19. Web site: A Low Methionine Diet: New Data for Cancer Therapy Favors Plant Foods. Kahn. Joel. 2019-08-05. Medium. en. 2019-12-28.
  20. Web site: You Can't 'Starve' Cancer, but You Might Help Treat It With Food. Hamblin. James. 2019-05-20. The Atlantic. en-US. 2019-12-08.
  21. Web site: Altering Diet to Enhance Cancer Treatment Response. 2019-09-03. National Cancer Institute. en. 2019-12-13.
  22. Web site: Feeding the Beast: Could Eating the Right Diet Starve Cancers Like Mine?. Stern. Adam Philip. 2019-06-17. Medium. 2019-12-01.
  23. Web site: Can diet help cancer treatment? Study in mice offers clues. news.yahoo.com. en-US. 2019-12-08.
  24. Web site: Mice fed a low-methionine diet respond better to cancer treatments. Chemical & Engineering News. en. 2019-12-08.
  25. Web site: HOME. Locasale Lab. 2019-12-01.
  26. 1970-01-01. Editorial Board. Cell Stress. en. 2523-0204.
  27. Web site: Deciphering cancer: The intersection of epigenetics, metabolism, and tumorigenesis. 2017-02-21. Science AAAS. 2019-12-01.
  28. Web site: PLOS Biology: A Peer-Reviewed Open-Access Journal. journals.plos.org. 2019-12-01.
  29. Web site: Oncotarget Editorial Board/Editors. www.oncotarget.com. 2020-01-03.
  30. Web site: NCI F99/K00 Award. 2015-12-29. National Cancer Institute. en. 2019-12-18.
  31. Web site: Student Honors and Laurels for 2019. today.duke.edu. en. 2019-12-18.
  32. Web site: School of Medicine Faculty Recognized on 'Highly Cited' List Duke School of Medicine. medschool.duke.edu. 2019-12-01.
  33. Web site: Highly Cited Researchers. publons.com. 2019-12-01.
  34. Web site: Global List of Highly Cited Puts Duke in Top Ten. today.duke.edu. en. 2019-12-25.

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