| Country: | JPN |
| Type: | National |
| Route: | 501 |
| Map Custom: | yes |
| Length Km: | 47.1 |
| Length Ref: | [1] |
| Established: | 1993 |
| Direction A: | North |
| Terminus A: | in Omuta, Fukuoka |
| Direction B: | South |
| Terminus B: | in Uto, Kumamoto |
| Previous Type: | Route |
| Previous Route: | 500 |
| Next Type: | Route |
| Next Route: | 502 |
National Route 501 is a national highway of Japan connecting between Omuta, Fukuoka and Uto, Kumamoto in Japan, with total length has 47.1 km (29.3 mi).