| Country: | JPN |
| Type: | National |
| Route: | 500 |
| Map Custom: | yes |
| Length Km: | 160.9 |
| Length Ref: | [1] |
| Established: | 1993 |
| Direction A: | West |
| Terminus A: | in Tosu, Saga |
| Direction B: | East |
| Terminus B: | in Beppu, Ōita |
| Previous Type: | Route |
| Previous Route: | 499 |
| Next Type: | Route |
| Next Route: | 501 |
National Route 500 is a national highway of Japan connecting Beppu, Ōita and Tosu, Saga on the island of Kyushu, with a total length of 160.9 km (99.98 mi).