| Country: | JPN |
| Type: | National |
| Route: | 50 |
| Map Custom: | yes |
| Length Km: | 144.2 |
| Length Ref: | [1] |
| Established: | 1 April 1963 |
| Direction A: | West |
| Terminus A: | in Maebashi |
| Direction B: | East |
| Terminus B: | and in Mito |
| Previous Type: | Route |
| Previous Route: | 49 |
| Next Type: | Route |
| Next Route: | 51 |
National Route 50 is a national highway of Japan connecting Maebashi and Mito.
Route 50 was designated on 18 May 1953 on the current route as National Route 122, and this was redesignated as Route 50 on 1 April 1963 when the route was promoted to a first-class highway.