| Country: | JPN |
| Type: | National |
| Route: | 272 |
| Map Custom: | yes |
| Image Notes: | Terminus of National Route 272 in Kushiro town. |
| Length Km: | 113.1 |
| Length Ref: | [1] |
| Established: | 1 April 1970 |
| Direction A: | North |
| Terminus A: | in Shibetsu |
| Direction B: | South |
| Terminus B: | in Kushiro |
| Previous Type: | Route |
| Previous Route: | 271 |
| Next Type: | Route |
| Next Route: | 273 |
National Route 272 is a national highway of Japan connecting Kushiro and Shibetsu in Japan, with a total length of 113.1 km (70.28 mi).