| Country: | JPN |
| Type: | National |
| Route: | 253 |
| Map Custom: | yes |
| Map Notes: | Japan National Route 253 highlighted in red |
| Length Km: | 67.8 |
| Length Ref: | [1] |
| Established: | 1 April 1963 |
| Previous Type: | Route |
| Previous Route: | 252 |
| Next Type: | Route |
| Next Route: | 254 |
National Route 253 is a national highway of Japan connecting Jōetsu, Niigata and Minamiuonuma, Niigata in Japan, with a total length of 67.8 km (42.13 mi).