| Country: | JPN |
| Type: | National |
| Route: | 250 |
| Map Custom: | yes |
| Length Km: | 146.3 |
| Length Ref: | [1] |
| Established: | 10 July 1956 |
| Direction A: | West |
| Terminus A: | in Okayama |
| Direction B: | East |
| Terminus B: | in Nagata-ku, Kobe |
| Previous Type: | Route |
| Previous Route: | 249 |
| Next Type: | Route |
| Next Route: | 251 |
National Route 250 is a national highway of Japan connecting Nagata-ku, Kobe and Okayama in Japan, with a total length of 146.3 km (90.91 mi).