| Country: | JPN |
| Type: | National |
| Route: | 222 |
| Map Custom: | yes |
| Length Km: | 55.2 |
| Length Ref: | [1] |
| Established: | 18 May 1953 |
| Direction A: | West |
| Terminus A: | in Miyakonojō |
| Direction B: | East |
| Terminus B: | in Nichinan |
| Previous Type: | Route |
| Previous Route: | 221 |
| Next Type: | Route |
| Next Route: | 223 |
National Route 222 is a national highway of Japan connecting Nichinan and Miyakonojō in Japan, with a total length of 55.2 km (34.3 mi).